A Reagentless Electrochemical DNA Sensor Based on a Self-Powered DNA Machine

被引：1
作者：
Huang, Ting [1 ,2 ]
Zhang, Wenxing [1 ,2 ]
Wie, Guobing [1 ,2 ]
Hong, Nian [1 ,2 ]
Wang, Mei [1 ,2 ]
Fan, Qiqi [1 ,2 ]
Yu, Qiangqiang [1 ,2 ]
Liao, Fusheng [1 ,2 ]
Fan, Hao [1 ,2 ]
机构：
[1] JiangXi Univ Chinese Med, Dept Pharm, Nanchang 330004, Jiangxi, Peoples R China
[2] JiangXi Univ Chinese Med, Affiliated Hosp, Nanchang 330004, Jiangxi, Peoples R China
来源：
ELECTROANALYSIS | 2023年 / 35卷 / 04期
基金：
美国国家科学基金会;
关键词：
Electrochemical DNA sensor; MOFs; Bisferrocene; Self-powered; Reagentless; SURVIVIN MESSENGER-RNA; BIOSENSOR; FRAMEWORK; FEATURES; WALKER;
D O I：
10.1002/elan.202200330
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Herein, a reagentless electrochemical DNA sensor based on a self-powered DNA machine for detecting survivin mRNA in cells is developed. The metal-organic framework (MOFs) loaded with DNAzyme cofactors (Mn2+) is coated on PTFE rods on the Au surface and assembled with the DNA walker, overcoming the complexity of adding metal ions from the external environment. In addition, the orbital chain is modified by a synthetic bisferrocene signal marker, which further enables signal amplification. Under optimal conditions, the sensor exhibits a range from 1x10(-14) mol/L to 1x10(-8) mol/L with a detection limit (S/N=3) of 1.28 fM.
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页数：9
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