The role of non-protein-coding RNAs in ischemic acute kidney injury

被引:2
作者
Sarvestani, Fatemeh Sabet [1 ]
Afshari, Afsoon [2 ]
Azarpira, Negar [1 ]
机构
[1] Shiraz Univ Med Sci, Shiraz Transplant Res Ctr, Shiraz, Iran
[2] Shiraz Univ Med Sci, Shiraz Nephrourol Res Ctr, Shiraz, Iran
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
noncoding RNAs; miRNAs; lncRNAs; circular RNAs; ischemia; acute kidney injury; RENAL ISCHEMIA/REPERFUSION INJURY; CRITICALLY-ILL PATIENTS; LONG NONCODING RNAS; NITRIC-OXIDE; CIRCULAR RNAS; ULTRACONSERVED REGION; MOLECULAR-MECHANISMS; REPERFUSION INJURY; PREDICTS SURVIVAL; OXIDATIVE STRESS;
D O I
10.3389/fimmu.2024.1230742
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Acute kidney injury (AKI) is a condition characterized by a rapid decline in kidney function within a span of 48 hours. It is influenced by various factors including inflammation, oxidative stress, excessive calcium levels within cells, activation of the renin-angiotensin system, and dysfunction in microcirculation. Ischemia-reperfusion injury (IRI) is recognized as a major cause of AKI; however, the precise mechanisms behind this process are not yet fully understood and effective treatments are still needed. To enhance the accuracy of diagnosing AKI during its early stages, the utilization of innovative markers is crucial. Numerous studies suggest that certain noncoding RNAs (ncRNAs), such as long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), play a central role in regulating gene expression and protein synthesis. These ncRNAs are closely associated with the development and recovery of AKI and have been detected in both kidney tissue and bodily fluids. Furthermore, specific ncRNAs may serve as diagnostic markers and potential targets for therapeutic interventions in AKI. This review aims to summarize the functional roles and changes observed in noncoding RNAs during ischemic AKI, as well as explore their therapeutic potential.
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页数:22
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