SERS-Based Optical Nanobiosensors for the Detection of Alzheimer's Disease

被引：11
作者：
Gao, Feng [1 ,2 ]
Li, Fang [1 ,2 ]
Wang, Jianhao [1 ,2 ]
Yu, Hang [1 ,2 ]
Li, Xiang [1 ,2 ]
Chen, Hongyu [1 ,2 ]
Wang, Jiabei [1 ,2 ]
Qin, Dongdong [1 ,2 ]
Li, Yiyi [1 ,2 ]
Liu, Songyan [1 ,2 ]
Zhang, Xi [1 ,2 ]
Wang, Zhi-Hao [1 ,2 ]
机构：
[1] Wuhan Univ, Renmin Hosp, Dept Neurol, Wuhan 430060, Peoples R China
[2] Wuhan Univ, Renmin Hosp, Ctr Neurodegenerat Dis Res, Wuhan 430060, Peoples R China
来源：
BIOSENSORS-BASEL | 2023年 / 13卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; SERS; nanoparticles; fluid biomarkers; disease diagnosis; biosensor; ENHANCED RAMAN-SPECTROSCOPY; BLOOD-BASED BIOMARKERS; SELECTIVE SEPARATION; TAU PATHOLOGY; AMYLOID-BETA; IDENTIFICATION; NANOPARTICLES; DIAGNOSIS; PATHOPHYSIOLOGY; DEGENERATION;
D O I：
10.3390/bios13090880
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Alzheimer's disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on surface-enhanced Raman scattering (SERS)-based biosensors, leveraging the excellent optical properties of nanomaterials to enhance detection performance. These highly sensitive and noninvasive biosensors offer opportunities for biomarker-driven clinical diagnostics and precision medicine. The review highlights various types of SERS-based biosensors targeting AD biomarkers, discussing their potential applications and contributions to AD diagnosis. Specific details about nanomaterials and targeted AD biomarkers are provided. Furthermore, the future research directions and challenges for improving AD marker detection using SERS sensors are outlined.
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页数：24
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