Models and approaches to comprehend and address glial inflammation following spinal cord injury

被引：7

作者：

Patil, Vaibhav ^{[1
]}

Bohara, Raghvendra ^{[1
]}

Kanala, Vijaya Krishna ^{[1
]}

Mcmahon, Siobhan ^{[2
]}

Pandit, Abhay ^{[1
]}

机构：

[1] Univ Galway, SFI Res Ctr Med Devices, CURAM, Galway, Ireland

[2] Univ Galway, Sch Med, Anat, Galway, Ireland

来源：

DRUG DISCOVERY TODAY | 2023年 / 28卷 / 10期

基金：

爱尔兰科学基金会;

关键词：

spinal cord injury; inflammation; high-throughput screening (HTS); microglia; astrocytes; COLONY-STIMULATING FACTOR; HIGH-DOSE METHYLPREDNISOLONE; BLOOD-BRAIN-BARRIER; NITRIC-OXIDE; NEUROPROTECTIVE THERAPY; EXTRACELLULAR-MATRIX; ENDOTHELIAL-CELLS; SODIUM SUCCINATE; MOUSE; IDENTIFICATION;

D O I：

10.1016/j.drudis.2023.103722

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Spinal cord injury (SCI) culminates in chronic inflammation and glial scar formation driven by the activation of microglia and astrocytes. Current anti-inflammatory strategies to treat glial activation associated with SCI have several limitations. Existing in vitro and ex vivo models studying molecular mechanisms associated with inflammation focus only on the acute phase. However, the progression of glial cell-derived inflammation over the acute-to-chronic phases has not been assessed. Understanding this progression will help establish a framework for evaluating therapeutic strategies. Additionally, new models could be useful as high-throughput screening (HTS) platforms. This review aims to highlight currently available models and future methods that could facilitate screening of novel therapeutics for SCI.

引用

页数：18

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