Restoring Epigenetic Reprogramming with Diet and Exercise to Improve Health-Related Metabolic Diseases

被引：19
作者：
Abraham, Merlin Jesso [1 ]
El Sherbini, Adham [1 ]
El-Diasty, Mohammad [2 ]
Askari, Sussan [3 ]
Szewczuk, Myron R. R. [1 ]
机构：
[1] Queens Univ, Dept Biomed & Mol Sci, Kingston, ON K7L 3N6, Canada
[2] Queens Univ, Kingston Hlth Sci Ctr, Dept Surg, Kingston, ON K7L 2V7, Canada
[3] Queens Univ, Dept Phys Med & Rehabil, Kingston, ON K7L 4X3, Canada
来源：
BIOMOLECULES | 2023年 / 13卷 / 02期
基金：
加拿大自然科学与工程研究理事会;
关键词：
diet; physical activity; health-related diseases; cardiovascular diseases; metabolic disorders; epigenome; epigenetic reprogramming; MATRIX-METALLOPROTEINASE-9; CROSS-TALK; RECEPTOR-SIGNALING PLATFORM; INDUCED CARDIAC GROWTH; ONE-CARBON METABOLISM; TOLL-LIKE RECEPTORS; NEU1; SIALIDASE; INDUCE TRANSACTIVATION; TARGETED TRANSLATION; DNA METHYLATION; NUTRITION;
D O I：
10.3390/biom13020318
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epigenetic reprogramming predicts the long-term functional health effects of health-related metabolic disease. This epigenetic reprogramming is activated by exogenous or endogenous insults, leading to altered healthy and different disease states. The epigenetic and environmental changes involve a roadmap of epigenetic networking, such as dietary components and exercise on epigenetic imprinting and restoring epigenome patterns laid down during embryonic development, which are paramount to establishing youthful cell type and health. Nutrition and exercise are among the most well-known environmental epigenetic factors influencing the proper developmental and functional lifestyle, with potential beneficial or detrimental effects on health status. The diet and exercise strategies applied from conception could represent an innovative epigenetic target for preventing and treating human diseases. Here, we describe the potential role of diet and exercise as therapeutic epigenetic strategies for health and diseases, highlighting putative future perspectives in this field.
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页数：19
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