An overview of poly(vinyl alcohol) and poly(vinyl pyrrolidone) in pharmaceutical additive manufacturing

被引:8
作者
Bianchi, Marica [1 ,2 ,3 ,4 ]
Pegoretti, Alessandro [1 ,2 ]
Fredi, Giulia [1 ,2 ]
机构
[1] Univ Trento, Dept Ind Engn, Trento, Italy
[2] Univ Trento, INSTM Unit, Trento, Italy
[3] Univ Trento, Dept Ind Engn, Via Sommar 9, I-38123 Trento, Italy
[4] Univ Trento, INSTM Unit, Via Sommar 9, I-38123 Trento, Italy
关键词
3D printing; FDM; personalized medicine; PVA; PVP; POLYVINYL-ALCOHOL; DRUG-RELEASE; 3D; FABRICATION; FORMULATIONS; MEDICINES; HYDROGEL; POLYMERS; DELIVERY; DEVICES;
D O I
10.1002/vnl.21982
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Recently, drug personalization has received noticeable attention. Problems arising from standard generalized drug treatments have aroused over the years, particularly among pediatric and geriatric patients. The growing awareness of the limitations of the "one-size-fits-all" approach has progressively led to a rethinking of the current medicine's development, laying the basis of personalized medicine. Three-dimensional printing is a promising tool for realizing personalized therapeutic solutions fitting specific patient needs. This technology offers the possibility to manufacture drug delivery devices with tailored doses, sizes, and release characteristics. Among additive manufacturing techniques, fused deposition modeling (FDM) is the most studied for oral drug delivery device production due to its high precision and cheapness. By playing with factors such as drug loading method, filament production, and printing parameters, the medication release profile of a drug delivery device produced by 3D printing can be tailored depending on the patient's requirements. This review focuses on the applications of FDM in drug fabrication using poly(vinyl alcohol) (PVA) and poly(vinyl pyrrolidone) (PVP) as drug-loaded matrices. The authors aim to provide an overview of the current trends in this research field, with special attention to the effect of the printing parameters, tablet shape, and drug distribution and concentration on drug customization and personalized drug release.
引用
收藏
页码:223 / 239
页数:17
相关论文
共 71 条
[1]   Chitosan filler effects on the experimental characterization, spectroscopic investigation and thermal studies of PVA/PVP blend films [J].
Abdelrazek, E. M. ;
Elashmawi, I. S. ;
Labeeb, S. .
PHYSICA B-CONDENSED MATTER, 2010, 405 (08) :2021-2027
[2]   Preparation and Characterization of Hydrogel Based on Poly(vinyl alcohol) Cross-Linked by Different Cross-Linkers Used to Dry Organic Solvents [J].
AL-Sabagh, A. M. ;
Abdeen, Z. .
JOURNAL OF POLYMERS AND THE ENVIRONMENT, 2010, 18 (04) :576-583
[3]  
Alice Konta Andrea, 2017, Bioengineering-Basel, V4, P79, DOI 10.3390/bioengineering4040079
[4]   Personalised dosing: Printing a dose of one's own medicine [J].
Alomari, Mustafa ;
Mohamed, Fatima H. ;
Basit, Abdul W. ;
Gaisford, Simon .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 494 (02) :568-577
[5]   Influence of openings and additional mass on vibration of laminated sandwich rhombic plates using IHSDT [J].
Anish ;
Kumar, Ajay ;
Chakrabarti, Anupam .
JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS, 2020, 33 (01) :3-34
[6]   Additive Manufacturing Strategies for Personalized Drug Delivery Systems and Medical Devices: Fused Filament Fabrication and Semi Solid Extrusion [J].
Auriemma, Giulia ;
Tommasino, Carmela ;
Falcone, Giovanni ;
Esposito, Tiziana ;
Sardo, Carla ;
Aquino, Rita Patrizia .
MOLECULES, 2022, 27 (09)
[7]   Advances in powder bed fusion 3D printing in drug delivery and healthcare [J].
Awad, Atheer ;
Fina, Fabrizio ;
Goyanes, Alvaro ;
Gaisford, Simon ;
Basit, Abdul W. .
ADVANCED DRUG DELIVERY REVIEWS, 2021, 174 :406-424
[8]   A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications [J].
Baker, Maribel I. ;
Walsh, Steven P. ;
Schwartz, Zvi ;
Boyan, Barbara D. .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2012, 100B (05) :1451-1457
[9]   Scenarios for 3D printing of personalized medicines - A case study [J].
Beer, Netta ;
Hegger, Ingrid ;
Kaae, Susanne ;
De Bruin, Marie Louise ;
Genina, Natalja ;
Alves, Teresa Leonardo ;
Hoebert, Joelle ;
Sporrong, Sofia Kalvemark .
EXPLORATORY RESEARCH IN CLINICAL AND SOCIAL PHARMACY, 2021, 4
[10]   Bone tissue engineering using 3D printing [J].
Bose, Susmita ;
Vahabzadeh, Sahar ;
Bandyopadhyay, Amit .
MATERIALS TODAY, 2013, 16 (12) :496-504