A Canine Surgical Model of Stroke by Minimally Invasive Occlusion of the Proximal Middle Cerebral Artery

被引：0

作者：

Liu, J. ^{[1
]}

Wang, Y. ^{[2
]}

Yin, J. ^{[2
]}

Zi, L. ^{[2
]}

Xiong, X. ^{[1
]}

Jian, Z. ^{[1
]}

机构：

[1] Wuhan Univ, Dept Neurosurg, Renmin Hosp, Wuhan, Hubei, Peoples R China

[2] Wuhan Univ, Cardiovasc Res Inst, Dept Cardiol, Hubei Key Lab Cardiol,Renmin Hosp, Wuhan, Hubei, Peoples R China

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 174卷 / 03期

关键词：

canine; ischemic stroke; animal models; surgical approach; middle cerebral artery; ISCHEMIC-STROKE;

D O I：

10.1007/s10517-023-05710-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In this study, a model of ischemic stroke by surgical proximal middle cerebral artery (MCA) occlusion was developed on 10 beagle dogs. The advantages of this model are the transtemporal approach and a minimally invasive surgical procedure. Dogs were randomly assigned to two groups: sham-operated (proximal MCA exposure without occlusion) and experimental (permanent proximal MCA occlusion) groups. Different evaluation methods were used to assess the consequences of MCA occlusion in dogs, including neurobehavioral tests, MRI, and immunohistochemical staining. Clear signs of cerebral infarction associated with the region supplied by MCA were confirmed and the model showed good repeatability and consistency. The model can serve as an appropriate large animal model to improve the translation of stroke therapeutics research from the laboratory to the clinical practice.

引用

页码：370 / 375

页数：6

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