The Journey Through the Pathogenesis and Treatment of Venous Thromboembolism in Inflammatory Bowel Diseases: A Narrative Review

被引：14

作者：

Boccatonda, Andrea ^{[1
,4
]}

Balletta, Marco ^{[2
]}

Vicari, Susanna ^{[1
]}

Hoxha, Ariela ^{[3
]}

Simioni, Paolo ^{[3
]}

Campello, Elena ^{[3
]}

机构：

[1] Bentivoglio Hosp, AUSL Bologna, Dept Internal Med, Bologna, Italy

[2] Bologna Univ, Dept Internal Med, Bologna, Italy

[3] Padova Univ Hosp, Dept Med DIMED, Hemorrhag & Thrombot Dis Unit, Padua, Italy

[4] Bentivoglio Hosp, Dept Internal Med, AUSL Bologna, Via Marconi Bentivoglio Hosp 35, I-40100 Bentivoglio, BO, Italy

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2023年 / 49卷 / 07期

关键词：

immunothrombosis; hypercoagulability; pulmonary embolism; thromboinflammation; venous thrombosis; VON-WILLEBRAND-FACTOR; FACTOR-V-LEIDEN; RISK-FACTORS; PROTEIN-C; EXTRAINTESTINAL MANIFESTATIONS; ACTIVATED RECEPTORS; THROMBIN GENERATION; ENDOTHELIAL-CELLS; VEIN-THROMBOSIS; CROHNS-DISEASE;

D O I：

10.1055/s-0042-1758869

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the gastrointestinal tract including Crohn's disease and ulcerative colitis, which may result in several extraintestinal complications (similar to 20-30% of cases), such as increased risk of venous thromboembolism (VTE). The main pathophysiological mechanism of VTE is an inflammation-induced hypercoagulable state, and recent data have shown that endothelial dysregulation due to gut and systemic inflammation may also lead to a prothrombotic state. Several prothrombotic alterations have been described, such as the activation of the coagulation system, platelet abnormalities, and dysregulation of fibrinolysis. Furthermore, the dysregulation of the gut microbiome seems to play a vital role in increasing systemic inflammation and thus inducing a procoagulant state. Our review aims to examine the main correlations between IBD and VTE, the underlying pathophysiology, and current therapeutic options.

引用

页码：744 / 755

页数：12

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