The Emerging Role of MAIT Cell Responses in Viral Infections

被引：16

作者：

Sandberg, Johan K. ^{[1
]}

Leeansyah, Edwin ^{[2
,3
]}

Eller, Michael A. ^{[4
]}

Shacklett, Barbara L. ^{[5
]}

Paquin-Proulx, Dominic ^{[6
,7
]}

机构：

[1] Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden

[2] Tsinghua Univ, Tsinghua Shenzhen Int Grad Sch, Inst Biopharmaceut & Hlth Engn, Shenzhen, Peoples R China

[3] Tsinghua Univ, Tsinghua Berkeley Shenzhen Inst, Precis Med & Healthcare Res Ctr, Shenzhen, Peoples R China

[4] Natl Inst Allergy & Infect Dis, Div AIDS, NIH, Bethesda, MD USA

[5] Univ Calif Davis, Sch Med, Dept Med Microbiol & Immunol, Davis, CA USA

[6] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA

[7] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA

来源：

JOURNAL OF IMMUNOLOGY | 2023年 / 211卷 / 04期

基金：

瑞典研究理事会;

关键词：

INVARIANT T-CELLS; ANTIGEN PRESENTATION; DENDRITIC CELLS; TISSUE-REPAIR; ACTIVATION; SIGNALS; SUBSET; TCR;

D O I：

10.4049/jimmunol.2300147

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mucosal-associated invariant T (MAIT) cells are unconventional T cells with innate-like antimicrobial responsiveness. MAIT cells are known for MR1 (MHC class I-related protein 1)-restricted recognition of microbial riboflavin metabolites giving them the capacity to respond to a broad range of microbes. However, recent progress has shown that MAIT cells can also respond to several viral infections in humans and in mouse models, ranging from HIV-1 and hepatitis viruses to influenza virus and SARS-CoV-2, in a primarily cognate Ag-independent manner. Depending on the disease context MAIT cells can provide direct or indirect antiviral protection for the host and may help recruit other immune cells, but they may also in some circumstances amplify inflammation and aggravate immunopathology. Furthermore, chronic viral infections are associated with varying degrees of functional and numerical MAIT cell impairment, suggesting secondary consequences for host defense. In this review, we summarize recent progress and highlight outstanding questions regarding the emerging role of MAIT cells in antiviral immunity.

引用

页码：511 / 517

页数：7

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