Trimethylamine N-oxide and risk of inflammatory bowel disease: A Mendelian randomization study

被引：5

作者：

Banno, Yukika ^{[1
]}

Nomura, Miho ^{[1
]}

Hara, Risako ^{[1
]}

Asami, Momoko ^{[1
]}

Tanaka, Kotone ^{[1
]}

Mukai, Yuuka ^{[1
]}

Tomata, Yasutake ^{[1
,2
]}

机构：

[1] Kanagawa Univ Human Serv, Fac Hlth & Social Serv, Sch Nutr & Dietet, Yokosuka, Kanagawa, Japan

[2] Kanagawa Univ Human Serv, Fac Hlth & Social Serv, Sch Nutr & Dietet, 1-10-1 Heisei Cho, Yokosuka, Kanagawa 2388522, Japan

来源：

MEDICINE | 2023年 / 102卷 / 34期

关键词：

Crohn disease; genome-wide association studies; inflammatory bowel disease; Mendelian randomization; trimethylamine N-oxide; ulcerative colitis; GENOME-WIDE ASSOCIATION; METABOLITES;

D O I：

10.1097/MD.0000000000034758

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A previous study suggested that inflammatory bowel disease (IBD) patients have low plasma levels of trimethylamine N-oxide (TMAO). In the present study, we examined this hypothesis using Mendelian randomization analysis. We used summary statistics data for single-nucleotide polymorphisms associated with plasma levels of TMAO, and the corresponding data for IBD from a genome-wide association meta-analysis of 59,957 individuals (25,042 diagnosed IBD cases, 34,915 controls). The association between genetically predicted plasma TMAO levels and IBD showed odds ratios (95% confidence interval [CI]) per 1 interquartile range increment (per 2.4 mu mol/L) in TMAO levels were 0.91 (0.81-1.01, P =.084) for IBD, 0.88 (0.76-1.02, P =.089) for ulcerative colitis, 0.91 (0.79-1.05, P =.210) for Crohn disease. There was no evidence for pleiotropy based on the Mendelian randomization-Egger regression analyses (P-intercept = 0.669 for IBD). Further investigations would be needed to understand the causal relationship between TMAO and IBD.

引用

页数：6

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