Association of Aortic Valve Calcification and High Levels of Lipoprotein (a): Systematic Review and Meta-Analysis

被引：3

作者：

Motawea, Karam R. ^{[1
]}

Elhalag, Rowan H. ^{[1
]}

Aboelenein, Merna ^{[1
]}

Ibrahim, Nancy ^{[1
]}

Swed, Sarya ^{[2
]}

Fathy, Hager ^{[3
]}

Awad, Dina M. ^{[1
]}

Belal, Mohamed Mohamed ^{[1
]}

Talaat, Nesreen E. ^{[1
]}

Rozan, Samah S. ^{[1
]}

Aiash, Hani ^{[4
]}

Mostafa, Mostafa Reda ^{[5
]}

机构：

[1] Alexandria Univ, Fac Med, Alexandria, Egypt

[2] Aleppo Univ, Fac Med, Aleppo, Syria

[3] Minia Univ, Fac Med, Al Minya, Egypt

[4] SUNY Upstate Med Univ, Cardiovasc Perfus Dept, Syracuse, NY USA

[5] Rochester Reg Hlth, Unity Hosp, Dept Med, Rochester, NY 14621 USA

来源：

CURRENT PROBLEMS IN CARDIOLOGY | 2023年 / 48卷 / 09期

关键词：

OXIDIZED PHOSPHOLIPIDS; RISK; STENOSIS; DISEASE;

D O I：

10.1016/j.cpcardiol.2023.101746

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study aimed to assess the association between aortic valve calcification and lipoprotein (a). We searched PUBMED, WOS, and SCOPUS data-bases. Inclusion criteria were any controlled clinical trials or observational studies that reported the level of Lipoprotein A in patients with aortic valve calcifica-tions, excluding case reports, editorials and animal studies. RevMan software (5.4) was used to perform the meta-analysis. After complete screening, 7 studies were included with a total number of 446,179 patients included in the analysis. The pooled analysis showed a statistically significant association between the inci-dence of aortic valve calcium and increased levels of lipoprotein (a) compared with controls (SMD = 1.71, 95% CI = 1.04-2.38, P-value < 0.00001). This meta - analysis showed a statistically significant association between the incidence of aortic valve calcium and increased levels of lipoprotein (a) compared with con-trols. Patients with high levels of lipoprotein (a) are at increased risk of developing aortic valve calcification. Medications targeting lipoprotein (a) in future clinical trials may be useful in primary prevention of aortic valve calcification in high risk patients. (Curr Probl Cardiol 2023;48:101746.)

引用

页数：23

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