The association between vitamin D status and inflammatory bowel disease among children and adolescents: A systematic review and meta-analysis

被引:9
作者
Fatahi, Somaye [1 ,2 ]
Alyahyawi, Naseem [3 ]
Albadawi, Naryman [4 ]
Mardali, Farzaneh [2 ]
Dara, Naghi [1 ]
Sohouli, Mohammad Hassan [5 ]
Prabahar, Kousalya [6 ]
Rohani, Pejman [7 ]
Koushki, Nazanin [2 ]
Sayyari, Aliakbar [1 ]
Hosseini, Amir Hossein [1 ]
Abu-Zaid, Ahmed [8 ]
机构
[1] Shahid Beheshti Univ Med Sci, Pediat Gastroenterol Hepatol & Nutr Res Ctr, Res Inst Childrens Hlth, Tehran, Iran
[2] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran
[3] King Abdulaziz Univ Hosp, Dept Pediat, Jeddah, Saudi Arabia
[4] King Faisal Specialist Hosp & Res Ctr, Dept Med, Riyadh, Saudi Arabia
[5] Shahid Beheshti Univ Med Sci, Student Res Comm, Dept Clin Nutr & Dietet, Fac Nutr & Food Technol, Tehran, Iran
[6] Univ Tabuk, Fac Pharm, Dept Pharm Practice, Tabuk, Saudi Arabia
[7] Univ Tehran Med Sci, Pediat Gastroenterol & Hepatol Res Ctr, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
[8] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia
来源
FRONTIERS IN NUTRITION | 2023年 / 9卷
关键词
vitamin D; inflammatory bowel disease (IBD); children; systematic review; supplement; BONE-MINERAL DENSITY; D DEFICIENCY; PEDIATRIC-PATIENTS; CROHNS-DISEASE; RISK-FACTORS; ADULTS;
D O I
10.3389/fnut.2022.1007725
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Aim: Vitamin D deficiency is very common among children with IBD. Since there are conflicting results regarding the association of vitamin D with IBD, we conducted this systematic review to confirm the association of vitamin D with IBD.Methods: We conducted a systematic search in Scopus, Cochrane Library, Web of Science, PubMed, and Google Scholar to find relevant studies. Articles with cross-sectional and case-control designs that reported the association between vitamin D and IBD among children were included.Results: Eventually, 9 studies (with 16 effect sizes) reported the mean and SD or the median and the interquartile range of serum vitamin D levels in both subjects with IBD and control subjects. The random effects meta-analysis revealed that subjects with IBD had -1.159 ng/ml (95% CI: -2.783, 0.464) lower serum vitamin D concentrations compared with their healthy counterparts, but this difference was not significant. A total of 14 studies (with 18 effect sizes) with 2,602 participants provided information for the prevalence of vitamin D deficiency or insufficiency in patients with IBD as 44% (95% CI: 0.34-0.54) with significant heterogeneity noted among studies (p < 0.001; I-2 = 97.31%).Conclusion: This systematic and meta-analysis study revealed that vitamin D deficiency was associated with IBD. Longitudinal studies should be conducted in the future to confirm our findings. Large randomized controlled trials assessing the doses of supplementation of vitamin D would provide a better understanding of the association between vitamin D and IBD.
引用
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页数:14
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