Current Insights into Diagnosis, Prevention Strategies, Treatment, Therapeutic Targets, and Challenges of Monkeypox (Mpox) Infections in Human Populations

被引:18
|
作者
Patel, Mitesh [1 ,2 ]
Adnan, Mohd [3 ]
Aldarhami, Abdu [4 ]
Bazaid, Abdulrahman S. [5 ]
Saeedi, Nizar H. [6 ]
Alkayyal, Almohanad A. [6 ]
Saleh, Fayez M. [7 ]
Awadh, Ibrahim B. [8 ]
Saeed, Amir [5 ]
Alshaghdali, Khalid [5 ]
机构
[1] Parul Univ, Dept Biotechnol, Parul Inst Appl Sci, Vadodara 391760, India
[2] Parul Univ, Ctr Res Dev, Vadodara 391760, India
[3] Univ Hail, Coll Sci, Dept Biol, POB 2440, Hail, Saudi Arabia
[4] Umm Al Qura Univ, Qunfudah Fac Med, Dept Med Microbiol, Al Qunfudah 21961, Saudi Arabia
[5] Univ Hail, Coll Appl Med Sci, Dept Med Lab Sci, Hail 55476, Saudi Arabia
[6] Univ Tabuk, Fac Appl Med Sci, Dept Med Lab Technol, Tabuk 71491, Saudi Arabia
[7] Univ Tabuk, Fac Med, Dept Med Microbiol, Tabuk 71491, Saudi Arabia
[8] Qunfudah Gen Hosp, Lab & Blood Bank Dept, Al Qunfudah 28821, Saudi Arabia
来源
LIFE-BASEL | 2023年 / 13卷 / 01期
关键词
Monkeypox virus; Mpox; orthopoxvirus; zoonotic disease; infectious diseases; emerging diseases; VACCINIA VIRUS; CRYSTAL-STRUCTURE; SMALLPOX; DISEASE; ORTHOPOXVIRUSES; IDENTIFICATION; OUTBREAK; VARIOLA; DRUGS; MODEL;
D O I
10.3390/life13010249
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In the wake of the emergence and worldwide respread of a viral infection called Monkeypox (Mpox), there is a serious threat to the health and safety of the global population. This viral infection was endemic to the western and central parts of Africa, but has recently spread out of this endemic area to various countries, including the United Kingdom (UK), Portugal, Spain, the United States of America (USA), Canada, Sweden, Belgium, Italy, Australia, Germany, France, the Netherlands, Israel, and Mexico. This is a timely review focusing on recent findings and developments in the epidemiology, clinical features, therapeutic targets, diagnosis, prevention mechanisms, research challenges and possible treatment for Mpox. To date (29 November 2022), there have been around 81,225 reported cases of Mpox. In most cases, this illness is mild; however, there is a fatality rate ranging from 1 to 10%, which might be increased due to associated complications and/or secondary infections. There is a real challenge in the diagnosis of Mpox, since its symptoms are very similar to those of other infections, including smallpox and chickenpox. Generally, to prevent/limit the risk and transmission of Mpox, the detection and isolation of infected individuals, as well as hand hygiene and cleanliness, are essential and effective approaches to control/combat this viral infection. Nevertheless, updated information about Mpox from different angles is lacking. Thus, this review provides updated and comprehensive information about the Mpox illness, which should highlight the global burden, pathogenicity, symptoms, diagnosis, prevention measures and possible treatment of this emerging disease.
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页数:17
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