Brain metastases and lung cancer: molecular biology, natural history, prediction of response and efficacy of immunotherapy

被引：12

作者：

Sereno, Maria ^{[1
,2
,3
,4
]}

de Cordoba, Irene Hernandez ^{[1
]}

Gutierrez-Gutierrez, Gerardo ^{[2
,3
,5
]}

Casado, Enrique ^{[1
,2
,3
,4
]}

机构：

[1] Infanta Sofia Univ Hosp, Med Oncol Dept, Madrid, Spain

[2] European Univ Madrid, Madrid, Spain

[3] Hosp Univ Infanta Sofia HUIS, Hosp Henares HHEN, Fdn Invest & Innovac Biomed FIIB, Madrid, Spain

[4] CEI Univ Autonoma Madrid UAM, Inst Madrileno Invest Estudios Avanzados IMDEA, Precis Nutr & Canc Program, Clin Oncol Grp,IMDEA Food Inst,Consejo Super Inv, Madrid 28049, Spain

[5] Infanta Sofia Univ Hosp, Neurol Dept, Madrid, Spain

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 14卷

关键词：

brain metastasis; organotropism; immunotherapy; abscopal effect; intracranial activity; EPITHELIAL-MESENCHYMAL TRANSITION; NIVOLUMAB PLUS IPILIMUMAB; OPEN-LABEL; 1ST-LINE TREATMENT; NSCLC; EXPRESSION; PEMBROLIZUMAB; CHEMOTHERAPY; DOCETAXEL; THERAPY;

D O I：

10.3389/fimmu.2023.1297988

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Brain metastases stemming from lung cancer represent a common and challenging complication that significantly impacts patients' overall health. The migration of these cancerous cells from lung lesions to the central nervous system is facilitated by diverse molecular changes and a specific environment that supports their affinity for neural tissues. The advent of immunotherapy and its varied combinations in non-small cell lung cancer has notably improved patient survival rates, even in cases involving brain metastases. These therapies exhibit enhanced penetration into the central nervous system compared to traditional chemotherapy. This review outlines the molecular mechanisms underlying the development of brain metastases in lung cancer and explores the efficacy of novel immunotherapy approaches and their combinations

引用

页数：13

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