Dietary puerarin supplementation improves immune function in the small intestines of oxidized oil-challenged broilers

被引：2

作者：

Zhou, Hua ^{[1
,2
]}

Yu, Yingmei ^{[1
,2
]}

Shi, Xuan ^{[1
,2
]}

Zou, Tiande ^{[1
,2
]}

Yang, Lei ^{[1
,2
]}

Ouyang, Jingxin ^{[1
,2
]}

Bian, Yinhao ^{[1
,2
]}

Liu, Yichun ^{[1
,2
]}

Li, Guanhong ^{[1
,2
]}

机构：

[1] Jiangxi Agr Univ, Coll Anim Sci & Technol, Jiangxi Prov Key Lab Anim Nutr, Nanchang 330045, Peoples R China

[2] Jiangxi Prov Key Innovat Ctr Integrat Prod & Educ, Nanchang, Peoples R China

来源：

ANIMAL SCIENCE JOURNAL | 2023年 / 94卷 / 01期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

broilers; inflammation; oxidized soybean oil; puerarin; small intestine; INFLAMMATORY RESPONSE; SIGNALING PATHWAY; MEAT QUALITY; ANTIOXIDANT; PERFORMANCE; ACTIVATION; EXPRESSION; CELLS; MICE; TLR4/NF-KAPPA-B;

D O I：

10.1111/asj.13895

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Puerarin has possessed a wide range of pharmacological activities. However, little is known about the protective effects of puerarin on the oxidized oil-induced injury. Here, we describe the anti-inflammatory effects of puerarin in chickens. A total of 360 broilers were arranged in four treatments. Diets included two types of soybean oil (fresh or oxidized) and two levels of puerarin (0 or 750 mg/kg). Results showed that puerarin alleviated oxidized soybean oil-induced intestinal immune injury by decreasing the expressions of HSP and pro-inflammatory factor (P < 0.05) and enhancing the mRNA levels of anti-inflammatory factor and CATH-1 (P < 0.05) in broilers. Moreover, puerarin supplementation decreased the mRNA abundances of TLR4 and MyD88 (P < 0.05) and upregulated the expressions of A20 and SOCS-1 (P < 0.05) in the small intestine of oxidized soybean oil-challenged broilers. Collectively, this study demonstrates puerarin may be a potential nutrient supplement in the treatment of oxidized oil-induced damage in poultry.

引用

页数：13

共 39 条

[1] Bao L., 2019, Effects of Lactobacillus rhamnosus on growth performance intestinal morphology and immune function of broilers under immune stress
[2] Effects of oxidized corn oil and a synthetic antioxidant blend on performance, oxidative status of tissues, and fresh meat quality in finishing barrows
Boler, D. D.
Fernandez-Duenas, D. M.
Kutzler, L. W.
Zhao, J.
Harrell, R. J.
Campion, D. R.
McKeith, F. K.
Killefer, J.
Dilger, A. C.
[J]. JOURNAL OF ANIMAL SCIENCE, 2012, 90 (13) : 5159 - 5169
[3] Fang L., 2020, AsianAustralasian Journal of Animal Sciences, V28, P1194
[4] Guang Hui-Juan, 2012, Zoological Research, V33, P523, DOI 10.3724/SP.J.1141.2012.05523
[5] Mycobacterium tuberculosis: Immune evasion, latency and reactivation
Gupta, Antima
Kaul, Akshay
Tsolaki, Anthony G.
Kishore, Uday
Bhakta, Sanjib
[J]. IMMUNOBIOLOGY, 2012, 217 (03) : 363 - 374
[6] Icariin Attenuates High-cholesterol Diet Induced Atherosclerosis in Rats by Inhibition of Inflammatory Response and p38 MAPK Signaling Pathway
Hu, Yanwu
Sun, Bo
Liu, Kai
Yan, Mengtong
Zhang, Yang
Miao, Chunsheng
Ren, Liqun
[J]. INFLAMMATION, 2016, 39 (01) : 228 - 236
[7] Toll-like receptors and their role in persistent pain
Lacagnina, Michael J.
Watkins, Linda R.
Grace, Peter M.
[J]. PHARMACOLOGY & THERAPEUTICS, 2018, 184 : 145 - 158
[8] L-Arginine Ameliorates Lipopolysaccharide-Induced Intestinal Inflammation through Inhibiting the TLR4/NF-κB and MAPK Pathways and Stimulating β-Defensin Expression in Vivo and in Vitro
Lan, Jing
Dou, Xiujing
Li, Jiawei
Yang, Yang
Xue, Chenyu
Wang, Chenxi
Gao, Nan
Shan, Anshan
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2020, 68 (09) : 2648 - 2663
[9] Li L, 2018, AM J TRANSL RES, V10, P957
[10] Transport Properties of Puerarin and Effect of Extract of Radix Angelicae dahuricae on Puerarin Intestinal Absorption Using In Situ and In Vitro Models
Liao, Zheng-Gen
Liang, Xin-Li
Zhu, Jing-Yun
Zhao, Guo-Wei
Guan, Yong-Mei
Cao, Yun-Chao
Zhao, Li-Jun
[J]. PHYTOTHERAPY RESEARCH, 2014, 28 (09) : 1288 - 1294

← 1 2 3 4 →