Targeting residual inflammatory risk: The next frontier for atherosclerosis treatment and prevention

被引：18

作者：

Ridker, Paul M. ^{[1
,2
,3
]}

机构：

[1] Brigham & Womens Hosp, Ctr Cardiovasc Dis Prevent, Div Prevent Med, Boston, MA USA

[2] Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA USA

[3] Brigham & Womens Hosp, Ctr Cardiovasc Dis Prevent, 900 Commonwealth Ave, Boston, MA 02215 USA

来源：

VASCULAR PHARMACOLOGY | 2023年 / 153卷

关键词：

Inflammation; Atherosclerosis; C-reactive protein; Colchicine; Interleukin-6; CORONARY-DISEASE; COLCHICINE; EVENTS;

D O I：

10.1016/j.vph.2023.107238

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inflammation and hyperlipidemia act synergistically to drive atherosclerotic progression. Multiple randomized trials now demonstrate that "lower is better" not only for LDLC, but also for hsCRP. Recent data among statin treated patients indicates that residual inflammatory risk is a stronger determinant of recurrent events than residual cholesterol risk. Based on trial data demonstrating a 31% reduction in events with minimal side effects, low-dose colchicine (0.5 mg daily) has been approved by the United States Food and Drug Administration to lower rates of myocardial infarction, stroke, and cardiovascular death as an adjunct to statin therapy. Physicians can anticipate novel anti-inflammatory agents in the future.

引用

页数：3

共 15 条

[1] Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials [J].

Fiolet, Aernoud T. L. ;

Opstal, Tjerk S. J. ;

Mosterd, Arend ;

Eikelboom, John W. ;

Jolly, Sanjit S. ;

Keech, Anthony C. ;

Kelly, Peter ;

Tong, David C. ;

Layland, Jamie ;

Nidorf, Stefan M. ;

Thompson, Peter L. ;

Budgeon, Charley ;

Tijssen, Jan G. P. ;

Cornel, Jan H. .

EUROPEAN HEART JOURNAL, 2021, 42 (28) :2765-2775

[2] Inflammation in Atherosclerosis-No Longer a Theory [J].

Libby, Peter .

CLINICAL CHEMISTRY, 2021, 67 (01) :131-142

[3] Low-Dose Colchicine for Secondary Prevention of Coronary Artery Disease JACC Review Topic of the Week [J].

Nelson, Kyle ;

Fuster, Valentin ;

Ridker, Paul M. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2023, 82 (07) :648-660

[4] Colchicine in Patients with Chronic Coronary Disease [J].

Nidorf, Stefan M. ;

Fiolet, Aernoud T. L. ;

Mosterd, Arend ;

Eikelboom, John W. ;

Schut, Astrid ;

Opstal, Tjerk S. J. ;

The, Salem H. K. ;

Xu, Xiao-Fang ;

Ireland, Mark A. ;

Lenderink, Timo ;

Latchem, Donald ;

Hoogslag, Pieter ;

Jerzewski, Anastazia ;

Nierop, Peter ;

Whelan, Alan ;

Hendriks, Randall ;

Swart, Henk ;

Schaap, Jeroen ;

Kuijper, Aaf F. M. ;

van Hessen, Maarten W. J. ;

Saklani, Pradyot ;

Tan, Isabel ;

Thompson, Angus G. ;

Morton, Allison ;

Judkins, Chris ;

Bax, Willem A. ;

Dirksen, Maurits ;

Alings, Marco ;

Hankey, Graeme J. ;

Budgeon, Charley A. ;

Tijssen, Jan G. P. ;

Cornel, Jan H. ;

Thompson, Peter L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (19) :1838-1847

[5] Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients [J].

Nissen, Steven E. ;

Menon, Venu ;

Nicholls, Stephen J. ;

Brennan, Danielle ;

Laffin, Luke ;

Ridker, Paul ;

Ray, Kausik K. ;

Mason, Denise ;

Kastelein, John J. P. ;

Cho, Leslie ;

Libby, Peter ;

Li, Na ;

Foody, JoAnne ;

Louie, Michael J. ;

Lincoff, A. Michael .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2023, 330 (02) :131-140

[6] New and Emerging Therapies for Reduction of LDL-Cholesterol and Apolipoprotein B [J].

Nurmohamed, Nick S. ;

Navar, Ann Marie ;

Kastelein, John J. P. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 77 (12) :1564-1575

[7] Drivers of mortality in patients with chronic coronary disease in the low-dose colchicine 2 trial [J].

Opstal, Tjerk S. J. ;

Nidorf, Stefan M. ;

Fiolet, Aernoud T. L. ;

Eikelboom, John W. ;

Mosterd, Arend ;

Bax, Willem A. ;

Budgeon, Charley A. ;

Ronner, Eelko ;

Prins, Fransisco J. ;

Tijssen, Jan G. P. ;

Schut, Astrid ;

Thompson, Peter L. ;

El Messaoudi, Saloua ;

Cornel, Jan H. .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2023, 372 :1-5

[8] Colchicine in Patients With Chronic Coronary Disease in Relation to Prior Acute Coronary Syndrome [J].

Opstal, Tjerk S. J. ;

Fiolet, Aernoud T. L. ;

van Broekhoven, Amber ;

Mosterd, Arend ;

Eikelboom, John W. ;

Nidorf, Stefan M. ;

Thompson, Peter L. ;

Duyvendak, Michiel ;

van Eck, J. W. Martijn ;

van Beek, Eugene A. ;

den Hartog, Frank ;

Budgeon, Charley A. ;

Bax, Willem A. ;

Tijssen, Jan G. P. ;

El Messaoudi, Saloua ;

Cornel, Jan H. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 78 (09) :859-866

[9] Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease [J].

Ridker, P. M. ;

Everett, B. M. ;

Thuren, T. ;

MacFadyen, J. G. ;

Chang, W. H. ;

Ballantyne, C. ;

Fonseca, F. ;

Nicolau, J. ;

Koenig, W. ;

Anker, S. D. ;

Kastelein, J. J. P. ;

Cornel, J. H. ;

Pais, P. ;

Pella, D. ;

Genest, J. ;

Cifkova, R. ;

Lorenzatti, A. ;

Forster, T. ;

Kobalava, Z. ;

Vida-Simiti, L. ;

Flather, M. ;

Shimokawa, H. ;

Ogawa, H. ;

Dellborg, M. ;

Rossi, P. R. F. ;

Troquay, R. P. T. ;

Libby, P. ;

Glynn, R. J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (12) :1119-1131

[10] Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein [J].

Ridker, Paul M. ;

Danielson, Eleanor ;

Fonseca, Francisco A. H. ;

Genest, Jacques ;

Gotto, Antonio M., Jr. ;

Kastelein, John J. P. ;

Koenig, Wolfgang ;

Libby, Peter ;

Lorenzatti, Alberto J. ;

MacFadyen, Jean G. ;

Nordestgaard, Borge G. ;

Shepherd, James ;

Willerson, James T. ;

Glynn, Robert J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (21) :2195-2207

← 1 2 →