Advances in immunotyping of colorectal cancer

被引：8

作者：

Wu, Yinhang ^{[1
,2
,3
]}

Zhuang, Jing ^{[1
,2
,3
]}

Qu, Zhanbo ^{[1
,2
,3
]}

Yang, Xi ^{[1
,2
,3
]}

Han, Shuwen ^{[1
,2
,3
]}

机构：

[1] Huzhou Univ, Huzhou Cent Hosp, Affiliated Cent Hosp, Huzhou, Peoples R China

[2] Key Lab Multiom Res & Clin Transformat Digest Canc, Huzhou, Peoples R China

[3] Zhejiang Chinese Med Univ, Huzhou Cent Hosp, Affiliated Clin Med Coll 5, Huzhou, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

colorectal cancer; immunotherapy; immune subtype; tumor immune microenvironment; colorectal cancer subtypes; TUMOR IMMUNE MICROENVIRONMENT; CONSENSUS MOLECULAR SUBTYPES; T-CELL INFILTRATION; IMMUNOTHERAPY; METHYLATION; PROGNOSIS; PROGRESSION; FERROPTOSIS; LANDSCAPE; SIGNATURE;

D O I：

10.3389/fimmu.2023.1259461

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunotherapy has transformed treatment for various types of malignancy. However, the benefit of immunotherapy is limited to a minority of patients with mismatch-repair-deficient (dMMR) and microsatellite instability-high (MSI-H) (dMMR-MSI-H) colorectal cancer (CRC). Understanding the complexity and heterogeneity of the tumor immune microenvironment (TIME) and identifying immune-related CRC subtypes will improve antitumor immunotherapy. Here, we review the current status of immunotherapy and typing schemes for CRC. Immune subtypes have been identified based on TIME and prognostic gene signatures that can both partially explain clinical responses to immune checkpoint inhibitors and the prognosis of patients with CRC. Identifying immune subtypes will improve understanding of complex CRC tumor heterogeneity and refine current immunotherapeutic strategies.

引用

页数：12

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