Exploring the role of gut microbiota in obesity and PCOS: Current updates and future prospects

被引：4

作者：

Zhang, Hui ^{[1
,2
]}

Butoyi, Claudette ^{[2
,3
]}

Yuan, Guoyue ^{[2
]}

Jia, Jue ^{[2
]}

机构：

[1] Jiangsu Univ, Clin Med Coll 1, Zhenjiang, Jiangsu, Peoples R China

[2] Jiangsu Univ, Affiliated Hosp, Inst Endocrine & Metab Dis, Dept Endocrinol & Metab, Zhenjiang, Jiangsu, Peoples R China

[3] Jiangsu Univ, Sch Med, Zhenjiang, Jiangsu, Peoples R China

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2023年 / 202卷

基金：

中国国家自然科学基金;

关键词：

Gut microbiota; PCOS; Obesity; Insulin resistance; Hyperandrogenemia; POLYCYSTIC-OVARY-SYNDROME; CHAIN FATTY-ACIDS; GLUCAGON-LIKE PEPTIDE-1; INSULIN-RESISTANCE; LUTEINIZING-HORMONE; SIGNAL-TRANSDUCTION; RECEPTOR; PROTEIN; WOMEN; METABOLISM;

D O I：

10.1016/j.diabres.2023.110781

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polycystic ovary syndrome (PCOS) is a common endocrine gynecological disorder, and the specific pathogenesis of PCOS has not been elucidated. Obesity is a current major public health problem, which is also vital to PCOS. It can exacerbate PCOS symptoms via insulin resistance and hyperandrogenemia. The treatment of PCOS patients depends on the prevailing symptoms. Lifestyle interventions and weight loss remain first-line treatments for women with PCOS. The gut microbiota, which is a current research hot spot, has a substantial influence on PCOS and is closely related to obesity. The present study aimed to elucidate the function of the gut microbiota in obesity and PCOS to provide new ideas for the treatment of PCOS.

引用

页数：7

共 85 条

[1] Childhood Obesity and Its Impact on the Development of Adolescent PCOS [J].

Anderson, Amy D. ;

Solorzano, Christine M. Burt ;

McCartney, Christopher R. .

SEMINARS IN REPRODUCTIVE MEDICINE, 2014, 32 (03) :202-213

[2] Des-acyl ghrelin inhibits the capacity of macrophages to stimulate the expression of aromatase in breast adipose stromal cells [J].

Au, CheukMan C. ;

Docanto, Maria M. ;

Zahid, Heba ;

Raffaelli, Francesca -Maria ;

Ferrero, Richard L. ;

Furness, John B. ;

Brown, Kristy A. .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2017, 170 :49-53

[3] The gut microbiota as an environmental factor that regulates fat storage [J].

Bäckhed, F ;

Ding, H ;

Wang, T ;

Hooper, LV ;

Koh, GY ;

Nagy, A ;

Semenkovich, CF ;

Gordon, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15718-15723

[4] The role of Gut Microbiota in the development of obesity and Diabetes [J].

Baothman, Othman A. ;

Zamzami, Mazin A. ;

Taher, Ibrahim ;

Abubaker, Jehad ;

Abu-Farha, Mohamed .

LIPIDS IN HEALTH AND DISEASE, 2016, 15

[5] Differential insulin and steroidogenic signaling in insulin resistant and non insulin resistant human luteinized granulosa cells - A study in PCOS patients [J].

Belani, Muskaan ;

Deo, Abhilash ;

Shah, Preeti ;

Banker, Manish ;

Singal, Pawan ;

Gupta, Sarita .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2018, 178 :283-292

[6] Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome [J].

Cadagan, David ;

Khan, Raheela ;

Amer, Saad .

REPRODUCTIVE BIOLOGY, 2016, 16 (01) :53-60

[7] Metabolic endotoxemia initiates obesity and insulin resistance [J].

Cani, Patrice D. ;

Amar, Jacques ;

Iglesias, Miguel Angel ;

Poggi, Marjorie ;

Knauf, Claude ;

Bastelica, Delphine ;

Neyrinck, Audrey M. ;

Fava, Francesca ;

Tuohy, Kieran M. ;

Chabo, Chantal ;

Waget, Aurelie ;

Delmee, Evelyne ;

Cousin, Beatrice ;

Sulpice, Thierry ;

Chamontin, Bernard ;

Ferrieres, Jean ;

Tanti, Jean-Francois ;

Gibson, Glenn R. ;

Casteilla, Louis ;

Delzenne, Nathalie M. ;

Alessi, Marie Christine ;

Burcelin, Remy .

DIABETES, 2007, 56 (07) :1761-1772

[8] Role and Mechanism of Gut Microbiota in Human Disease [J].

Chen, Yinwei ;

Zhou, Jinghua ;

Wang, Li .

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2021, 11

[9] Effect of acute physiological free fatty acid elevation in the context of hyperinsulinemia on fiber type-specific IMCL accumulation [J].

Chow, Lisa S. ;

Mashek, Douglas G. ;

Wang, Qi ;

Shepherd, Sam O. ;

Goodpaster, Bret H. ;

Dube, John J. .

JOURNAL OF APPLIED PHYSIOLOGY, 2017, 123 (01) :71-78

[10] Importance of gut microbiota in obesity [J].

Cornejo-Pareja, Isabel ;

Munoz-Garach, Araceli ;

Clemente-Postigo, Mercedes ;

Tinahones, Francisco J. .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2019, 72 (Suppl 1) :26-37

← 1 2 3 4 5 6 7 8 9 →