Aneugenic and clastogenic alterations in the DBA/IJ mouse model of rheumatoid arthritis treated with rituximab, an anti-CD20 antibody

被引：3

作者：

Attia, Sabry M. ^{[1
]}

Al-Hamamah, Mohammed A. ^{[1
]}

Alotaibi, Moureq R. ^{[1
]}

Alasmari, Abdullah F. ^{[1
]}

Attia, Mohamed S. M. ^{[1
]}

Ahmad, Sheikh F. ^{[1
]}

Mahmoud, Mohamed A. ^{[1
]}

Nadeem, Ahmed ^{[1
]}

Ansari, Mushtaq A. ^{[1
]}

Bakheet, Saleh A. ^{[1
]}

机构：

[1] King Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, Riyadh 11451, Saudi Arabia

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2023年 / 888卷

关键词：

Anti-CD20; Inflammation; Aneugenicity; Clastogenicity; Oxidative DNA damage; 8-OHdG; IN-SITU HYBRIDIZATION; OXIDATIVE STRESS; GENOMIC DNA; MICRONUCLEI; DAMAGE; DIFFERENTIATION; ABERRATIONS; NICOTINE; CELLS;

D O I：

10.1016/j.mrgentox.2023.503635

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Rheumatoid arthritis (RA), an autoimmune disorder in which the immune system attacks healthy cells, is associated with elevated risk of lymphoma. Rituximab, a treatment for non-Hodgkin's lymphoma, has been approved as a treatment for RA. We studied the effects of rituximab on chromosomal stability in collagen -induced arthritis DBA/1J animal models. Micronucleus levels were increased in the mouse models, mainly due to chromosome loss, as detected by fluorescence in situ hybridization; rituximab-treated arthritic mice had significantly less micronucleus formation. Serum 8-hydroxydeoxyguanosine, a DNA oxidative stress marker, was increased in the mice models but reduced following rituximab administration.

引用

页数：6

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