Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice

被引：3

作者：

Kang, Wen ^{[1
]}

Wu, Li ^{[1
]}

Chen, Cheng ^{[1
]}

Xie, Weige ^{[1
]}

Chen, Jiaqi ^{[1
]}

Song, Shiyu ^{[1
,2
]}

Huang, Lingyan ^{[1
]}

Wang, Hongwei ^{[1
,2
]}

Xie, Sijing ^{[1
]}

机构：

[1] Nanjing Univ, Nanjing Stomatol Hosp, Dept Endodont, Med Sch, Nanjing 210008, Peoples R China

[2] Nanjing Univ, State Key Lab Analyt Chem Life Sci, Jiangsu Key Lab Mol Med, Med Sch, Nanjing 210093, Peoples R China

来源：

HELIYON | 2023年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Psoriasis; Imiquimod; Human dental pulp stem cells; SKIN INFLAMMATION; ADIPOSE-TISSUE; MOUSE MODEL; DIFFERENTIATION; PROLIFERATION; KERATINOCYTES; DERMATOSIS; GROWTH; IL-17; TOOL;

D O I：

10.1016/j.heliyon.2023.e13337

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Psoriasis is an autoimmune disease, which has a significant impact on the quality of patient's life. And, there is still no cure for psoriasis. The human dental pulp stem cell (hDPSC) possesses the properties of immunoregulation. In this study, we aimed to determine the effect of hDPSC on the imiquimod (IMQ)-induced psoriasis in mice. The psoriasis model was established by topical application of IMQ cream in mice for 7 days. We found that subcutaneous injection of hDPSC could reduce the symptoms of skin lesions in IMQ-induced psoriasis and suppress the expression of keratin 16, S100A8, S100A9, which are associated with abnormal epidermal proliferation. Subepithelial inflammatory cytokines, CD4+ T lymphocytes and CD11c+ dendritic cells in-filtrations were significantly inhibited in by hDPSC. The TNF-alpha, IFN-gamma expressions in serum were decreased, and splenomegaly induced by IMQ was improved after hDPSC treatment. In summary, our study demonstrated that hDPSC could reduce the symptoms of skin lesions and suppress local and systemic immune responses of IMQ-induced psoriasis in mice, which might provide a new sight for the treatment of psoriasis.

引用

页数：12

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