Immunothrombosis: Molecular Aspects and New Therapeutic Perspectives

被引：23
|
作者：
Marcos-Jubilar, Maria [1 ]
Lecumberri, Ramon [1 ,2 ]
Paramo, Jose A. [1 ,3 ]
机构：
[1] Clin Univ Navarra, Hematol & Hemotherapy Serv, Pamplona 31008, Spain
[2] Inst Salud Carlos III, CIBER CV, Madrid 28029, Spain
[3] Inst Invest Sanitaria Navarra IdiSNA, Pamplona 31008, Spain
来源：
JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 04期
关键词：
immunothrombosis; thromboinflammation; tissue factor; NEUTROPHIL EXTRACELLULAR TRAPS; TISSUE FACTOR EXPRESSION; GASDERMIN D; INTRAVASCULAR COAGULATION; INNATE IMMUNITY; THROMBOSIS; ACTIVATION; PLATELETS; HEMOSTASIS; DECRYPTION;
D O I：
10.3390/jcm12041399
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Thromboinflammation or immunothrombosis is a concept that explains the existing link between coagulation and inflammatory response present in many situations, such as sepsis, venous thromboembolism, or COVID-19 associated coagulopathy. The purpose of this review is to provide an overview of the current data regarding the mechanisms involved in immunothrombosis in order to understand the new therapeutic strategies focused in reducing thrombotic risk by controlling the inflammation.
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页数：11
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