Role of Platelets in Rheumatic Chronic Autoimmune Inflammatory Diseases

被引：3

作者：

Pec, Martin Jozef ^{[1
]}

Jurica, Jakub ^{[1
]}

Pecova, Monika ^{[2
,3
]}

Benko, Jakub ^{[1
,4
]}

Sokol, Juraj ^{[3
]}

Bolek, Tomas ^{[1
]}

Samec, Marek ^{[5
]}

Hurtova, Tatiana ^{[6
,7
]}

Galajda, Peter ^{[1
]}

Samos, Matej ^{[1
,8
,9
]}

Mokan, Marian ^{[1
]}

机构：

[1] Comenius Univ, Jessenius Fac Med Martin, Dept Internal Med 1, Martin, Slovakia

[2] Teaching Hosp Martin, Oncol Ctr, Martin, Slovakia

[3] Comenius Univ, Jessenius Fac Med Martin, Natl Ctr Hemostasis & Thrombosis, Dept Hematol & Transfusiol, Martin, Slovakia

[4] Teaching Hosp Nitra, Dept Cardiol, Nitra, Slovakia

[5] Comenius Univ, Jessenius Fac Med Martin, Dept Med Biol, Martin, Slovakia

[6] Comenius Univ, Jessenius Fac Med Martin, Dept Dermatovenerol, Martin, Slovakia

[7] Comenius Univ, Jessenius Fac Med Martin, Dept Infectol & Travel Med, Martin, Slovakia

[8] Midslovakian Inst Heart & Vessel Dis SUSCCH a s, Dept Cardiol & Angiol 2, Div Acute & Intervent Cardiol, As Banska Bystr, Banska Bystrica, Slovakia

[9] Comenius Univ, Jessenius Fac Med Martin, Dept Internal Med 1, Kollarova 203659, Martin, Slovakia

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2024年 / 50卷 / 04期

关键词：

psoriasis; systemic sclerosis; systemic lupus erythematosus; chronic inflammatory arthritis; SOLUBLE P-SELECTIN; ANKYLOSING-SPONDYLITIS; CARDIOVASCULAR RISK; LYMPHOCYTE RATIO; PSORIASIS-VULGARIS; DISTRIBUTION WIDTH; SEVERITY INDEX; PLASMA-LEVELS; TNF-ALPHA; VOLUME;

D O I：

10.1055/s-0043-1777071

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelets are essential in maintaining blood homeostasis and regulating several inflammatory processes. They constantly interact with immune cells, have immunoregulatory functions, and can affect, through immunologically active substances, endothelium, leukocytes, and other immune response components. In reverse, inflammatory and immune processes can activate platelets, which might be significant in autoimmune disease progression and arising complications. Thus, considering this interplay, targeting platelet activity may represent a new approach to treatment of autoimmune diseases. This review aims to highlight the role of platelets in the pathogenic mechanisms of the most frequent chronic autoimmune inflammatory diseases to identify gaps in current knowledge and to provide potential new targets for medical interventions.

引用

页码：609 / 619

页数：11

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