An update on the developments in the treatment of adult T-cell leukemia-lymphoma: current knowledge and future perspective

被引：4

作者：

Makiyama, Junya ^{[1
,6
]}

Ishitsuka, Kenji ^{[2
]}

Munakata, Wataru ^{[3
]}

Maruyama, Dai ^{[4
]}

Nagai, Hirokazu ^{[5
]}

机构：

[1] Sasebo City Gen Hosp, Dept Hematol, Sasebo, Japan

[2] Kagoshima Univ, Dept Hematol & Rheumatol, Kagoshima, Japan

[3] Natl Canc Ctr, Dept Hematol, Tokyo, Japan

[4] Canc Inst Hosp Japanese Fdn Canc Res, Dept Hematol Oncol, Tokyo, Japan

[5] Natl Hosp Org Nagoya Med Ctr, Clin Res Ctr, Nagoya, Japan

[6] Sasebo City Gen Hosp, Dept Hematol, 9-3 Hirase Cho, Sasebo, Nagasaki 8578511, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2023年 / 53卷 / 12期

关键词：

adult T-cell leukemia-lymphoma; clinical trials; Japan Clinical Oncology Group; ANTI-CCR4 ANTIBODY MOGAMULIZUMAB; CORD BLOOD TRANSPLANTATION; PROGNOSTIC INDEX; INTERFERON-ALPHA; LONG-TERM; COMBINATION CHEMOTHERAPY; BRENTUXIMAB VEDOTIN; ELDERLY-PATIENTS; LEUKEMIA/LYMPHOMA; JAPAN;

D O I：

10.1093/jjco/hyad108

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Indolent adult T-cell leukemia-lymphoma is treated with watchful waiting, whereas aggressive adult T-cell leukemia-lymphoma requires chemotherapy. New evidence from clinical trials is required to improve the prognosis of patients with adult T-cell leukemia-lymphoma. Adult T-cell leukemia-lymphoma is defined as peripheral T-cell lymphoma caused by the human T-cell leukemia virus type I. Adult T-cell leukemia-lymphoma is classified into indolent (favorable chronic or smoldering) or aggressive (acute, lymphoma or unfavorable chronic) types. This review discusses the therapeutic developments for patients with adult T-cell leukemia-lymphoma and unmet issues in treating adult T-cell leukemia-lymphoma. For indolent adult T-cell leukemia-lymphoma, a watchful waiting strategy is recommended until the disease progresses to aggressive adult T-cell leukemia-lymphoma. For aggressive adult T-cell leukemia-lymphoma, multi-agent chemotherapy with or without allogeneic hematopoietic stem cell transplantation has been recommended. However, many patients with adult T-cell leukemia-lymphoma relapse, and their prognosis is poor. Recently, novel agents, including mogamulizumab, lenalidomide, brentuximab vedotin, tucidinostat and valemetostat, have been approved for patients with relapsed or refractory aggressive adult T-cell leukemia-lymphoma, and the combination of mogamulizumab with multi-agent chemotherapy or brentuximab vedotin with cyclophosphamide, doxorubicin and prednisone has been approved for patients with untreated aggressive adult T-cell leukemia-lymphoma in Japan. Importantly, the aging of patients with adult T-cell leukemia-lymphoma has recently been reported, and no standard of care for elderly patients with adult T-cell leukemia-lymphoma has been established. New evidence must be obtained from prospective clinical trials to improve the prognosis of patients with adult T-cell leukemia-lymphoma.

引用

页码：1104 / 1111

页数：8

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