The roles of gut microbiota and its metabolites in diabetic nephropathy

被引：31

作者：

Zhao, Hui ^{[1
,2
]}

Yang, Cheng-E ^{[3
]}

Liu, Tian ^{[1
]}

Zhang, Ming-Xia ^{[1
]}

Niu, Yan ^{[1
]}

Wang, Ming ^{[4
]}

Yu, Jun ^{[1
]}

机构：

[1] Northwest Univ, Affiliated Xian Int Med Ctr Hosp, Clin Expt Ctr, Xian Engn Technol Res Ctr Cardiovasc Act Peptides, Xian, Shaanxi, Peoples R China

[2] Northwest Univ, Fac Life Sci & Med, Xian, Shaanxi, Peoples R China

[3] Xian Int Med Ctr Hosp, Dept Cardiol, Xian, Shaanxi, Peoples R China

[4] Northwest Univ, Coll Food Sci & Engn, Xian, Shaanxi, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2023年 / 14卷

关键词：

diabetic nephropathy; gut microbiota; microbial metabolites; gut-kidney axis; microbiota-targeted therapies; CHRONIC KIDNEY-DISEASE; P-CRESYL SULFATE; HYDROGEN-SULFIDE; HIGH GLUCOSE; INTESTINAL BARRIER; INSULIN-RESISTANCE; OXIDATIVE STRESS; MESANGIAL CELLS; RENAL FIBROSIS; SOY MILK;

D O I：

10.3389/fmicb.2023.1207132

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes, which increases the risk of renal failure and causes a high global disease burden. Due to the lack of sustainable treatment, DN has become the primary cause of end-stage renal disease worldwide. Gut microbiota and its metabolites exert critical regulatory functions in maintaining host health and are associated with many pathogenesis of aging-related chronic diseases. Currently, the theory gut-kidney axis has opened a novel angle to understand the relationship between gut microbiota and multiple kidney diseases. In recent years, accumulating evidence has revealed that the gut microbiota and their metabolites play an essential role in the pathophysiologic processes of DN through the gut-kidney axis. In this review, we summarize the current investigations of gut microbiota and microbial metabolites involvement in the progression of DN, and further discuss the potential gut microbiota-targeted therapeutic approaches for DN.

引用

页数：23

共 214 条

[1]

Abbasi B, 2017, IRAN J KIDNEY DIS, V11, P36

[2] Gut microbiota disorders cause type 2 diabetes mellitus and homeostatic disturbances in gut-related metabolism in Japanese subjects [J].

Adachi, Kazunori ;

Sugiyama, Tomoya ;

Yamaguchi, Yoshiharu ;

Tamura, Yasuhiro ;

Izawa, Shinya ;

Hijikata, Yasutaka ;

Ebi, Masahide ;

Funaki, Yasushi ;

Ogasawara, Naotaka ;

Goto, Chiho ;

Sasaki, Makoto ;

Kasugai, Kunio .

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 2019, 64 (03) :231-238

[3] Exogenous Hydrogen Sulfide (H2S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats [J].

Ahmad, Fiaz Ud Din ;

Sattar, Munavvar Abdul ;

Rathore, Hassaan Anwer ;

Abdullah, Mohammed Hadi ;

Tan, Samual ;

Abdullah, Nor Azizan ;

Johns, Edward James .

RENAL FAILURE, 2012, 34 (02) :203-210

[4] Hydrogen sulfide modulates SIRT1 and suppresses oxidative stress in diabetic nephropathy [J].

Ahmed, Hanan H. ;

Taha, Fatma M. ;

Omar, Heba S. ;

Elwi, Heba M. ;

Abdelnasser, Marwa .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2019, 457 (1-2) :1-9

[5] Gut Microbiota-Dependent Trimethylamine-N-oxide and Serum Biomarkers in Patients with T2DM and Advanced CKD [J].

Al-Obaide, Mohammed A. I. ;

Singh, Ruchi ;

Datta, Palika ;

Rewers-Felkins, Kathy A. ;

Salguero, Maria V. ;

Al-Obaidi, Ibtisam ;

Kottapalli, Kameswara Rao ;

Vasylyeva, Tetyana L. .

JOURNAL OF CLINICAL MEDICINE, 2017, 6 (09)

[6] Antibiotics and chronic kidney disease: Dose adjustment update for infectious disease clinical practice [J].

Aloy, B. ;

Launay-Vacher, V. ;

Bleibtreu, A. ;

Bortolotti, P. ;

Faure, E. ;

Filali, A. ;

Gauzit, R. ;

Gilbert, M. ;

Lesprit, P. ;

Mahieu, R. ;

Meyssonnier, V. ;

Ogielska, M. ;

Romaru, J. ;

Salmon, D. ;

Alfandari, S. ;

Lemaignen, A. .

MEDECINE ET MALADIES INFECTIEUSES, 2020, 50 (04) :323-331

[7] Influence of exercise training on diabetic kidney disease: A brief physiological approach [J].

Amaral, Liliany Souza de Brito ;

Souza, Claudia Silva ;

Lima, Hernando Nascimento ;

Soares, Telma de Jesus .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2020, 245 (13) :1142-1154

[8] The Effects of Probiotic Honey Consumption on Metabolic Status in Patients with Diabetic Nephropathy: a Randomized, Double-Blind, Controlled Trial (Publication with Expression of Concern) [J].

Arani, Navid Mazruei ;

Emam-Djomeh, Zahra ;

Tavakolipour, Hamid ;

Sharafati-Chaleshtori, Reza ;

Soleimani, Alireza ;

Asemi, Zatollah .

PROBIOTICS AND ANTIMICROBIAL PROTEINS, 2019, 11 (04) :1195-1201

[9] Serum indoxyl sulfate levels in patients with diabetic nephropathy: Relation to renal function [J].

Atoh, Keita ;

Itoh, Hiroshi ;

Haneda, Masakazu .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2009, 83 (02) :220-226

[10] Renal primary cilia lengthen in the progression of diabetic kidney disease [J].

Bai, Yunfeng ;

Li, Ping ;

Liu, Jiaona ;

Zhang, Lu ;

Cui, Shaoyuan ;

Wei, Cuiting ;

Fu, Bo ;

Sun, Xuefeng ;

Cai, Guangyan ;

Hong, Quan ;

Chen, Xiangmei .

FRONTIERS IN ENDOCRINOLOGY, 2022, 13

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