Comparison of survival outcomes following radiotherapy versus radical hysterectomy in patients with stage IIA cervical squamous cell carcinoma

被引:0
作者
Li, Mingwei [1 ,2 ]
Liu, Ping [1 ]
Wang, Danbo [3 ]
Duan, Hui [1 ]
Zhan, Xuemei [2 ]
Zhang, Yi [4 ]
Xie, Qinghuang [5 ]
Chen, Biliang [6 ]
Cui, Zhumei [7 ]
Lv, Qiubo [8 ]
Wang, Hailin [9 ]
Bin, Xiaonong [10 ]
Lang, Jinghe [11 ]
Chen, Chunlin [1 ]
机构
[1] Southern Med Univ, Nanfang Hosp, Dept Obstet & Gynecol, Guangzhou 510000, Guangdong, Peoples R China
[2] Jiangmen Cent Hosp, Dept Gynecol, Jiangmen 529030, Guangdong, Peoples R China
[3] Liaoning Canc Hosp, Dept Gynecol, Shenyang 110801, Liaoning, Peoples R China
[4] China Med Univ, Hosp 1, Dept Gynecol, Shenyang 110001, Liaoning, Peoples R China
[5] Foshan Women & Children Hosp, Dept Obstet & Gynecol, Foshan 528099, Guangdong, Peoples R China
[6] Airforce Med Univ, Xijing Hosp, Dept Obstet & Gynecol, Xian 710032, Shaanxi, Peoples R China
[7] Qingdao Univ, Dept Gynecol, Affiliated Hosp, Qingdao 266003, Shandong, Peoples R China
[8] Beijing Hosp, Dept Obstet & Gynecol, Beijing 100730, Peoples R China
[9] Gansu Prov Hosp, Dept Obstet & Gynecol, Lanzhou 730020, Gansu, Peoples R China
[10] Guangzhou Med Univ, Coll Publ Hlth, Dept Epidemiol, Guangzhou 511495, Guangdong, Peoples R China
[11] Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Obstet & Gynecol, Beijing 100005, Peoples R China
关键词
Cervical cancer; Radical hysterectomy; Radiotherapy; Overall survival; Disease-free survival; RADIATION-THERAPY; IB; SURGERY; CANCER; COMPLICATIONS; METASTASIS;
D O I
10.22514/ejgo.2023.021
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This study explored the differences in survival outcomes of cervical squamous cell carcinoma (SCC) patients diagnosed with stage IIA who underwent radical hysterectomy (RH) versus radiotherapy (RT). Eligible stage IIA cervical SCC cases were screened from the C4 database. They were divided into RH and RT groups based on their treatments and in a 1:2 ratio utilizing propensity score matching (PSM). Their 5-year overall survival (OS) and disease-free survival (DFS) before and after PSM were compared. Before PSM analysis, the results showed that patients from the RT group (n = 421) had significantly poorer 5-year OS and DFS rates compared with the RH group (n = 761) (OS: 77.2% vs. 85.6%, p < 0.001, HR = 1.789; DFS: 74.9% vs. 80.0%, p = 0.006, HR = 1.447). After stratification in a 1:2 ratio, PSM analysis results showed that the 5-year OS and DFS rates of stage IIA1 patients from the RT group (n = 226) were significantly poorer than the RH group (n = 429) (OS: 78.1% vs. 87.2%, p < 0.001, HR = 2.203; DFS: 78.2% vs. 83.7%, p = 0.011, HR = 1.681), while no significant difference in 5-year OS and DFS rates were observed between the RT (n = 173) and RH (n = 266) groups (OS: 75.2% vs. 83.8%, p = 0.054; DFS: 71.4% vs. 79.5%, p = 0.070) of stage IIA2 patients. RH was associated with better OS and DFS outcomes than RT in cervical SCC patients diagnosed with stage IIA disease. Subgroup analyses showed that RH had superior OS and DFS benefits than RT in stage IIA1 cases, while no significant difference in survival was observed for stage IIA2 patients.
引用
收藏
页码:42 / 49
页数:8
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