Biological Activities of Ruthenium NHC Complexes: An Update

被引：13

作者：

Catalano, Alessia ^{[1
]}

Mariconda, Annaluisa ^{[2
]}

Sinicropi, Maria Stefania ^{[3
]}

Ceramella, Jessica ^{[3
]}

Iacopetta, Domenico ^{[3
]}

Saturnino, Carmela ^{[2
]}

Longo, Pasquale ^{[4
]}

机构：

[1] Univ Bari Aldo Moro, Dept Pharm Drug Sci, I-70126 Bari, Italy

[2] Univ Basilicata, Dept Sci, I-85100 Potenza, Italy

[3] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy

[4] Univ Salerno, Dept Chem & Biol, Via Giovanni Paolo II, 132, I-84084 Fisciano, Italy

来源：

ANTIBIOTICS-BASEL | 2023年 / 12卷 / 02期

关键词：

Ru-NHC complexes; N-heterocyclic carbenes; antitumor agents; antiproliferative activity; antibacterials; antimicrobials; antifungals; HETEROCYCLIC CARBENE COMPLEXES; CRYSTAL-STRUCTURE; ANTICANCER; CYTOTOXICITY; LIGANDS; CATALYSIS; AGENTS; GOLD;

D O I：

10.3390/antibiotics12020365

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Ruthenium N-heterocyclic carbene (NHC) complexes have unique physico-chemical properties as catalysts and a huge potential in medicinal chemistry and pharmacology, exhibiting a variety of notable biological activities. In this review, the most recent studies on ruthenium NHC complexes are summarized, focusing specifically on antimicrobial and antiproliferative activities. Ruthenium NHC complexes are generally active against Gram-positive bacteria, such as Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus, Listeria monocytogenes and are seldom active against Gram-negative bacteria, including Salmonella typhimurium, Pseudomonas aeruginosa and Escherichia coli and fungal strains of Candida albicans. The antiproliferative activity was tested against cancer cell lines of human colon, breast, cervix, epidermis, liver and rat glioblastoma cell lines. Ruthenium NHC complexes generally demonstrated cytotoxicity higher than standard anticancer drugs. Further studies are needed to explore the mechanism of action of these interesting compounds.

引用

页数：18

共 93 条

[91] Ruthenium Complex HB324 Induces Apoptosis via Mitochondrial Pathway with an Upregulation of Harakiri and Overcomes Cisplatin Resistance in Neuroblastoma Cells In Vitro [J].