Medically Refractory Lymphocytic Colitis Successfully Treated With Upadacitinib

被引：5

作者：

Miyatani, Yusuke ^{[1
]}

Choi, David ^{[1
]}

Du, Xiaotang ^{[2
]}

Hart, John ^{[2
]}

Rubin, David T. ^{[1
]}

机构：

[1] Univ Chicago Med, Inflammatory Bowel Dis Ctr, Dept Med, Chicago, IL 60637 USA

[2] Univ Chicago Med, Dept Pathol, Chicago, IL USA

来源：

ACG CASE REPORTS JOURNAL | 2023年 / 10卷 / 02期

关键词：

lymphocytic colitis; microscopic colitis; upadacitinib; MICROSCOPIC COLITIS; THERAPY;

D O I：

10.14309/crj.0000000000000979

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Lymphocytic colitis is a microscopic colitis characterized endoscopically by nearly normal-appearing colonic mucosa and histology demonstrating intraepithelial lymphocytosis. Microscopic colitis that is refractory to conventional therapies, including budesonide, is rare but challenging and with scarce evidence. Upadacitinib is a novel Janus kinase 1 selective inhibitor approved by the US Food and Drug Administration for atopic dermatitis, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and moderately to severely active ulcerative colitis. We present the first case of lymphocytic colitis refractory to conventional and immunosuppressive therapies, which responded promptly to upadacitinib.

引用

页数：4

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