Photochemical Synthesis of S,N,O-Containing Polyheterocycles via an a-C(sp3)-H Functionalization/Radical Cyclization Cascade

被引：9

作者：

Cheng, Shi-Yan ^{[1
]}

Liao, Jia-Bin ^{[1
]}

Lin, Yu-Mei ^{[1
]}

Gong, Lei ^{[1
,2
]}

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China

[2] Innovat Lab Sci & Technol Energy Mat Fujian Prov, Xiamen 361005, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 35期

基金：

中国国家自然科学基金;

关键词：

C-H ALKYLATION; PHOTOREDOX CATALYSIS; METHYL SULFIDES; N-ENYNES; ALKENES; BOND;

D O I：

10.1021/acs.orglett.3c02423

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly effective approach based on an organophotocatalytic a-C(sp(3))-H functionalization/radical cyclization cascade has been developed. This method enables the synthesis of various tricyclic heterocycles containing S, O, and N atoms with excellent site selectivity and diastereoselectivity. Mechanistic investigations have confirmed that the reaction involves photoredox-triggered C(sp(3))-H cleavage followed by a radical cyclization and aromatization process. These findings are expected to pave the way for developing cost-effective tandem radical reactions and synthesizing heterocyclic drugs.

引用

页码：6566 / 6570

页数：5

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