Respiratory Infections in the Aging Lung: Implications for Diagnosis, Therapy, and Prevention

被引：24

作者：

Haeder, Antje ^{[1
]}

Koese-Vogel, Nilay ^{[1
]}

Schulz, Luise ^{[1
]}

Mlynska, Lucja ^{[2
]}

Hornung, Franziska ^{[1
]}

Hagel, Stefan ^{[3
]}

Teichgraeber, Ulf ^{[2
]}

Lang, Susanne M. ^{[4
]}

Pletz, Mathias W. ^{[3
]}

Le Saux, Claude Jourdan ^{[5
]}

Loeffler, Bettina ^{[1
]}

Deinhardt-Emmer, Stefanie ^{[1
,6
,7
]}

机构：

[1] Jena Univ Hosp, Inst Med Microbiol, Klinikum 1, D-07747 Jena, Germany

[2] Jena Univ Hosp, Dept Radiol, Jena, Germany

[3] Friedrich Schiller Univ Jena, Jena Univ Hosp, Inst Infect Dis & Infect Control, Jena, Germany

[4] Jena Univ Hosp, Clin Internal Med 5, Pneumol, Jena, Germany

[5] Univ Calif San Francisco, Med Pulm & Crit Care Div, San Francisco, CA USA

[6] Leibniz Inst Photon Technol, Albert Einstein Str 9, Jena, Germany

[7] Res Alliance Leibniz Hlth Technol, Albert Einstein Str 9, Jena, Germany

来源：

AGING AND DISEASE | 2023年 / 14卷 / 04期

关键词：

Aging; lung; pneumonia; microbiological diagnostic; radiological procedures; therapy; vaccination; COMMUNITY-ACQUIRED PNEUMONIA; SYNCYTIAL VIRUS; INCREASED SUSCEPTIBILITY; PNEUMOCOCCAL PNEUMONIA; FUNGAL-INFECTIONS; CONJUGATE VACCINE; DISEASES-SOCIETY; RISK-FACTORS; INFLUENZA; MANAGEMENT;

D O I：

10.14336/AD.2023.0329

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Respiratory infections pose a significant health problem among elderly individuals, particularly during the COVID-19 pandemic. The increased mortality and morbidity rates among individuals over 65 highlight the criticality of these infections. The normal aging process in the lungs increases vulnerability to respiratory infections due to the accumulation of cellular damage and senescence. Consequently, the lung environment undergoes major changes in mechanical function and other systemic factors. This review aims to examine the influence of aging on respiratory infections from a clinical perspective by analyzing clinical studies. Additionally, the review will emphasize potential prevention and diagnostic developments to enhance therapy options available for elderly patients over 65 years of age.

引用

页码：1091 / 1104

页数：14

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