Synthesis and bio-evaluation of novel acyl derivatives of karanjin

被引：1

作者：

Eanti, Anjaneyulu ^{[1
]}

Kuncha, Madhusudana ^{[2
]}

Arundha, Ande ^{[2
]}

Misra, Sunil ^{[2
,4
]}

Vidavalur, Siddaiah ^{[3
]}

Ramakrishna, Sistla ^{[2
,4
]}

Kanjilal, Sanjit ^{[1
,4
]}

机构：

[1] CSIR, Indian Inst Chem Technol, Ctr Lipid Sci & Technol, Hyderabad 500007, India

[2] CSIR, Indian Inst Chem Technol, Appl Biol Div, Hyderabad 500007, India

[3] Andhra Univ, Coll Sci & Technol, Visakhapatnam 530003, India

[4] CSIR HRDC Campus, Acad Sci & Innovat Res AcSIR, Postal Staff Coll Area Sect 19, Ghaziabad 201002, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY | 2023年 / 62卷 / 02期

关键词：

Synthesis; Karanjin; Lipoconjugated karanjin; Anticancer; Anti-inflammatory; Antimicrobial activity; FURANOFLAVONOIDS;

D O I：

10.56042/ijc.v62i2.66256

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Different lipidic moieties such as 10-undecenoic, oleic, lipoic, caproic, caprylic and lauric acids have been acylated to demethylated karanjin to prepare six lipoconjugated karanjin. All the derivatives have been evaluated for antimicrobial, anticancer and antiinflammatory activities and compared with karanjin and its demethylated analog. Lipoconjugation does not seem to improve the activity of karanjin against studied bacterial and fungal strains. However, karanjin, demethylated karanjin and six lipoconjugated karanjin show moderate to good anticancer activity against prostate and breast cancer cell lines. Mild antiinflammatory response has also been observed in case of karanjin and lipoic acid-conjugated karanjin.

引用

页码：115 / 120

页数：6

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