Age and Sex Affect Essential Tremor (ET) Plus: Clinical Heterogeneity in ET Based on the National Survey in China

被引：13

作者：

Sun, Qiying ^{[1
,2
]}

He, Runcheng ^{[1
,2
]}

Huang, Hongyan ^{[3
]}

Cao, Hongmei ^{[4
]}

Wang, Xuejing ^{[5
]}

Liu, Hong ^{[6
]}

Wang, Chunyu ^{[7
]}

Lei, Lifang ^{[8
]}

Wang, Puqing ^{[9
]}

Cui, Guiyun ^{[10
]}

Ma, Jianjun ^{[11
]}

Gu, Ping ^{[12
]}

An, Di ^{[13
]}

Jia, Min ^{[14
]}

Sun, Zhanfang ^{[15
]}

Wu, Heng ^{[16
]}

Lin, Jinsheng ^{[17
]}

Tang, Jiayu ^{[18
]}

Zhou, Xun ^{[1
,2
]}

Li, Mingqiang ^{[16
]}

Zeng, Sheng ^{[19
]}

Chen, Yase ^{[1
,2
]}

Yan, Xinxiang ^{[1
,2
]}

Guo, Jifeng ^{[1
,2
]}

Xu, Qian ^{[1
,2
]}

Liu, Zhenhua ^{[1
,2
]}

Shen, Lu ^{[1
,2
,24
]}

Jiang, Hong ^{[1
,2
,24
]}

Wu, Xinyin ^{[20
]}

Xiao, Qin ^{[21
,22
]}

Chen, Haibo ^{[23
]}

Xu, Yanming ^{[3
]}

Tang, Beisha ^{[1
,2
,24
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Neurol, Dept Geriatr Neurol, Changsha, Hunan, Peoples R China

[2] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Neurol, Chengdu, Peoples R China

[4] Xi An Jiao Tong Univ, Dept Neurol, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China

[5] Zhengzhou Univ, Dept Neurol, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China

[6] Changzhi Med Coll, Dept Neurol, Heping Hosp, Changzhi, Shangxi, Peoples R China

[7] Cent South Univ, Dept Neurol, Xiangya Hosp 2, Changsha, Hunan, Peoples R China

[8] Cent South Univ, Dept Neurol, Xiangya Hosp 3, Changsha, Hunan, Peoples R China

[9] Hubei Univ Med, Dept Neurol, Xiang Yang Peoples Hosp 1, Xiangyang, Hubei, Peoples R China

[10] Xuzhou Med Univ, Dept Neurol, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China

[11] Henan Prov Peoples Hosp, Dept Neurol, Zhengzhou, Henan, Peoples R China

[12] Hebei Med Univ, Dept Neurol, Hosp 1, Shijiazhuang, Hebei, Peoples R China

[13] Hebei Univ, Dept Neurol, Affiliated Hosp, Baoding, Hebei, Peoples R China

[14] Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Dept Neurol, Enshi, Hubei, Peoples R China

[15] Shandong First Med Univ, Dept Neurol, Shandong Prov Hosp, Jinan, Shandong, Peoples R China

[16] Univ South China, Dept Neurol, Affiliated Hosp 1, Hengyang, Hunan, Peoples R China

[17] Xiangtan Cent Hosp, Dept Neurol, Xiangtan, Hunan, Peoples R China

[18] Hunan Prov Brain Hosp, Dept Neurol, Changsha, Hunan, Peoples R China

[19] Cent South Univ, Xiangya Hosp 2, Dept Geriatr Neurol, Changsha, Hunan, Peoples R China

[20] Cent South Univ, Xiangya Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha, Hunan, Peoples R China

[21] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Neurol, Shanghai, Peoples R China

[22] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Inst Neurol, Shanghai, Peoples R China

[23] Beijing Hosp, Natl Ctr Gerontol, Dept Neurol, Beijing, Peoples R China

[24] Cent South Univ, Key Lab Hunan Prov Neurodegenerat Disorders, Changsha, Hunan, Peoples R China

来源：

AGING AND DISEASE | 2023年 / 14卷 / 04期

基金：

中国国家自然科学基金;

关键词：

essential tremor; essential tremor plus; the national survey of essential tremor plus in china; registry study; clinical heterogeneity; DISEASE; SCALE;

D O I：

10.14336/AD.2022.1205

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The new term essential tremor (ET) plus was proposed in the 2018 tremor consensus criteria. The National Survey of Essential Tremor Plus in China, a large multicenter registry study, aimed to evaluate the clinical features of pure ET and ET plus and explore possible factors related to ET plus. All patients with ET underwent neurological examination and neuropsychological assessment at 17 clinical sites. The diagnosis was made according to the 2018 consensus criteria. Clinicodemographic characteristics were analyzed. A total of 1160 patients were included, including 546 patients with pure ET and 614 patients with ET plus. The proportion of females was significantly higher in the ET plus than that in the pure ET (P = 0.001). The age at onset (AAO) of pure ET showed a bimodal distribution, with peaks in the 2nd and 5th decades. However, the AAO of the ET plus group demonstrated a skewed distribution, with a single peak in the 6th decade. Female sex (OR=1.645, P<0.001), older age (OR=1.023, P<0.001), lower educational level (OR=0.934, P<0.001), head tremor (OR=1.457, P<0.001), and higher the Tremor Research Group Essential Tremor Rating Assessment Scale (TETRAS)-II scores (OR=1.134, P<0.001) were significantly associated with ET plus. Old age and female sex may contribute to ET plus development. Pure ET showed a bimodal distribution for AAO, whereas ET plus showed a unimodal distribution. It remains unclear whether pure ET and ET plus are merely different stages of a single disease or represent distinct disease entities.

引用

页码：1360 / 1373

页数：14

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