Thromboembolic complications of Mycoplasma pneumoniae pneumonia in children

被引：32

作者：

Chen, Lanqin ^{[1
]}

Yin, Ju ^{[1
]}

Liu, Xiuyun ^{[1
]}

Liu, Jun ^{[1
]}

Xu, Baoping ^{[1
]}

Shen, Kunling ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Childrens Hosp, Natl Clin Res Ctr Resp Dis, Natl Ctr Childrens Hlth,Dept Resp Dis I, Beijing, Peoples R China

[2] Capital Med Univ, Beijing Childrens Hosp, Natl Clin Res Ctr Resp Dis, Natl Ctr Childrens Hlth,Dept Resp Dis I, Beijing 100045, Peoples R China

来源：

CLINICAL RESPIRATORY JOURNAL | 2023年 / 17卷 / 03期

关键词：

children; Mycoplasma pneumoniae; pneumonia; thromboembolism; VENOUS THROMBOEMBOLISM; ANTIPHOSPHOLIPID ANTIBODIES; PULMONARY-EMBOLISM; UNITED-STATES; CHILDHOOD; INFECTION; DIAGNOSIS; RISK;

D O I：

10.1111/crj.13584

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

BackgroundThromboembolism is less common in children than in adults, but it is frequently associated with Mycoplasma pneumoniae infection in many cases. This study aimed to investigate the clinical characteristics of pediatric M. pneumoniae pneumonia complicated with thromboembolism. MethodsHospitalized patients with M. pneumoniae pneumonia complicated by thromboembolism were enrolled from January 2012 to December 2021 in Beijing Children's Hospital, Capital Medical University, China. The data on clinical manifestations, laboratory tests, and treatment were evaluated. ResultsA total of 49 cases were enrolled, with a mean age of 7.9 years old, including 27 boys and 22 girls. Consolidation of pulmonary lobe or segment was observed in 95.9% (47/49) of the cases, whereas interstitial change was found only in two patients; 85.7% (42/49) of patients had pleural effusion. Pulmonary vascular thromboembolism was most common in 35 patients, whereas 13 cases had thromboembolism of multiple anatomic sites. The levels of C-reaction protein, lactate dehydrogenase, and erythrocyte sedimentation rate were all increased, with a mean value of 54.08 +/- 52.27 g/L, 451.12 +/- 218.76 U/L, 43.40 +/- 29.43 mm/h, respectively. Blood coagulation test showed that all 49 patients had elevated D-dimer values (median 3.81 ng/ml, range, 0.34-48 ng/ml) and normal PT. aPTT.LA was positive in 74.3% (26/35) of the cases. aCL-IgM was positive in 66.7% (26/39) of the cases. a beta 2GPI-IgM was positive in 79.4% (27/34) of the cases. The prognosis was generally good in this group. ConclusionPulmonary arteriovenous thromboembolism is the most common thromboembolism complicated in MPP, and cerebral artery embolism and cardiac thrombosis are common in extrapulmonary thromboembolism. In the cases of MPP with thromboembolic complications, pulmonary consolidation with pleural effusion is the main characteristic. About two thirds of the cases are positive for antiphospholipid antibodies.

引用

页码：187 / 196

页数：10

共 27 条

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