Rearranged Homoadamantane-Type Polycyclic Polyprenylated Acylphloroglucinols from Hypericum pseudohenryi

被引：9

作者：

Jiang, Na-Na ^{[1
,2
,3
]}

Ye, Yan-Song ^{[1
,2
]}

Liu, Xia ^{[4
]}

Wang, Yong-Ling ^{[5
]}

Xu, Gang ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Chi, Kunming 650201, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Chongqing Hosp Tradit Chinese Med, Chongqing 400021, Peoples R China

[5] Zunyi Med Univ, Affiliated Hosp, Dept Pharm, Zunyi 563003, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 50期

基金：

中国科学院西部之光基金;

关键词：

D O I：

10.1021/acs.orglett.3c03143

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hypseudohenones A-C (1-3), the first rearranged homoadamantane-type polycyclic polyprenylated acylphloroglucinols, were isolated from Hypericum pseudohenryi. Their structures with an unprecedented tricyclo-[4.3.1.1(3,8)]-undecane-2,4,10-trione core were determined by spectroscopic analysis, quantum-chemical calculations, and X-ray crystallography. A method for determining the relative configuration at C-3 was established by the peak shape of H-28 or J-value of H-3/H-28. Moreover, 2-3 exhibited significant AChE inhibitory activity, and the interactions of 2-3 with AChE were evaluated by molecular docking.

引用

页码：8965 / 8969

页数：5

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