Noncardiac anomalies in children with congenital heart disease

被引：2
作者：
Huang, Xianghui [1 ,2 ]
Gao, Yuan [1 ,3 ]
Chen, Weicheng [1 ,3 ]
Sheng, Wei [1 ,3 ,4 ]
Huang, Guoying [1 ,3 ,4 ]
机构：
[1] Fudan Univ, Cardiovasc Ctr, Childrens Hosp, Shanghai, Peoples R China
[2] Xiamen Childrens Hosp, Fujian Key Lab Neonatal Dis, Fujian, Peoples R China
[3] Shanghai Key Lab Birth Defects, Shanghai, Peoples R China
[4] Unit Early Intervent Genet Related Childhood Cardi, Shanghai, Peoples R China
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2023年 / 10卷
基金：
中国国家自然科学基金;
关键词：
congenital heart defects; noncardiac anomalies; Chinese children; retrospective analyses; phenotype; EXTRACARDIAC ABNORMALITIES; CARDIAC-MALFORMATIONS; DEFECTS; ATLANTA;
D O I：
10.3389/fcvm.2023.1293210
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
IntroductionNoncardiac anomalies (NCAs) in patients with congenital heart defects (CHDs) are crucial for perioperative management and etiology studies. This study aimed to investigate NCAs in Chinese children with CHDs.MethodsMedical records for CHD-diagnosed children hospitalized from 1 January 2015 to 31 December 2019 were collected and subjected to retrospective analyses to excavate potential association rules between CHDs and noncardiac malformations.ResultsA total of 3,788 CHD patients were included in this study. The main phenotypes of CHD were Ventricular Septal Defect (VSD, 33.69%), Atrial Septal Defect (ASD, 12.72%), and Tetralogy of Fallot (TOF, 5.54%). A total of 887 (23.42%) cases showed noncardiac anomalies, which were mainly associated with the central nervous system (34.61%), nose/ear/mandibular/face (19.39%), genitourinary system (15.78%), and musculoskeletal system (15.56%). Compared to other CHD subtypes, septal defects had a lower percentage of associated NCAs (P = 3.7 x 10-9) while AVSD had a higher percentage (P = 0.0018).DisscussionNCAs are prevalent among CHD-diagnosed children in China, and the spectrums of NCAs in different CHD subcategories were different.
引用
收藏
页数：8
相关论文
共 44 条
[1]   Geriatric Congenital Heart Disease Burden of Disease and Predictors of Mortality [J].
Afilalo, Jonathan ;
Therrien, Judith ;
Pilote, Louise ;
Ionescu-Ittu, Raluca ;
Martucci, Giuseppe ;
Marelli, Ariane J. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 58 (14) :1509-1515
[2]   2 Synflorix™: What Have We Learned From Immunogenicity Studies? [J].
J Wysocki .
Pediatric Research, 2010, 68 (Suppl 1) :1-2
[3]   Critical Congenital Heart DiseaseuUtility of Routine Screening for Chromosomal and Other Extracardiac Malformations [J].
Baker, Kimberly ;
Sanchez-de-Toledo, Joan ;
Munoz, Ricardo ;
Orr, Richard ;
Kiray, Shareen ;
Shiderly, Dana ;
Clemens, Michele ;
Wearden, Peter ;
Morell, Victor O. ;
Chrysostomou, Constantinos .
CONGENITAL HEART DISEASE, 2012, 7 (02) :145-150
[4]   Temporal variability in birth prevalence of congenital heart defects as recorded by a general birth defects registry [J].
Bosi, G ;
Garani, G ;
Scorrano, M ;
Calzolari, E .
JOURNAL OF PEDIATRICS, 2003, 142 (06) :690-698
[5]   Seeking causes: Classifying and evaluating congenital heart defects in etiologic studies [J].
Botto, Lorenzo D. ;
Lin, Angela E. ;
Riehle-Colarusso, Tiffany ;
Malik, Sadia ;
Correa, Adolfo .
BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 2007, 79 (10) :714-727
[6]   Recurrence of congenital heart defects among siblings-a nationwide study [J].
Brodwall, Kristoffer ;
Greve, Gottfried ;
Leirgul, Elisabeth ;
Tell, Grethe S. ;
Vollset, Stein E. ;
Oyen, Nina .
AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2017, 173 (06) :1575-1585
[7]   Congenital heart defects: 15 Years of experience of the Emilia-Romagna Registry (Italy) [J].
E. Calzolari ;
G. Garani ;
G. Cocchi ;
C. Magnani ;
F. Rivieri ;
A. Neville ;
G. Astolfi ;
A. Baroncini ;
L. Garavelli ;
F. Gualandi ;
M. Scorrano ;
G. Bosi .
European Journal of Epidemiology, 2003, 18 (8) :773-780
[8]   Prevalence of associated extracardiac anomalies in prenatally diagnosed congenital heart diseases [J].
Chang, Chi-Son ;
Hong, Sir-yeon ;
Kim, Seo-yeon ;
Kim, Yoo-min ;
Sung, Ji-Hee ;
Choi, Suk-Joo ;
Oh, Soo-young ;
Roh, Cheong-Rae ;
Song, Jinyoung ;
Huh, June ;
Kang, I-Seok .
PLOS ONE, 2021, 16 (03)
[9]   Spectrum of congenital heart defects in Croatia [J].
Dilber, Daniel ;
Malcic, Ivan .
EUROPEAN JOURNAL OF PEDIATRICS, 2010, 169 (05) :543-550
[10]   A population-based study of extra-cardiac anomalies in children with congenital cardiac malformations [J].
Eskedal, L ;
Hagemo, P ;
Eskild, A ;
Aamodt, G ;
Seller, KS ;
Thaulow, E .
CARDIOLOGY IN THE YOUNG, 2004, 14 (06) :600-607
12345