Employing carbon quantum dots to combat cytomegalovirus

被引：6

作者：

Bulat, Tanja ^{[1
]}

Zmejkoski, Danica ^{[2
]}

Markovic, Zoran ^{[2
]}

Satzinger, Melissa ^{[2
]}

Kovac, Janez ^{[3
]}

Strobl, Birgit ^{[1
]}

Milivojevic, Dusan ^{[2
]}

Markovic, Biljana Todorovic ^{[2
]}

机构：

[1] Univ Vet Med Vienna, Dept Biomed Sci, Inst Anim Breeding & Genet, A-1210 Vienna, Austria

[2] Natl Inst Republ Serbia, Inst Nucl Sci Vinca, Mike Alasa 12-14, Belgrade 11001, Serbia

[3] Jozef Stefan Inst, Dept Surface Engn F4, Jamova Cesta 39, Ljubljana 1000, Slovenia

来源：

MATERIALS CHEMISTRY AND PHYSICS | 2024年 / 311卷

基金：

奥地利科学基金会;

关键词：

Carbon quantum dots; Citric acid; Pyrolysis; Cytomegalovirus; Interferon-stimulated gene; INHIBITORS; VIRUS;

D O I：

10.1016/j.matchemphys.2023.128495

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Carbon quantum dots (CQDs) are well known as a promising therapeutic agent due to their excellent pro-oxidant, antioxidant, antibacterial and anticancer properties under visible light irradiation. This material is easy to produce by several bottom-up or top-down methods. In this study, we used citric acid as starting precursor to synthesize aqueous carbon quantum dots dispersion by pyrolysis at 210 degrees C. Atomic force microscopy and XPS analyses revealed that CQDs synthesized are quasi-spherical with typical diameter of 9 nm and lots of C-O and C--O functional groups distributed over the basal plane and edges of the dots. Here, we investigated the antiviral properties of CQDs against cytomegalovirus (CMV). The pre-treatment with CQDs upregulates interferonstimulated genes (ISG), resulting in better virus control. Cellular defence against cytomegalovirus of CQDs pre-treated cells is increased in a dose-dependent manner. Our results reveal high biocompatibility and potent in vitro antiviral properties of CQDs.

引用

页数：8

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