Two New Benzofulvene Sesquiterpenoids from the Stems of Nicotiana tabacum and their Antibacterial Activity

被引：2

作者：

Shang, Shan-Zhai ^{[1
,2
]}

Dai, Jia-Meng ^{[1
]}

Xiong, Wen ^{[1
]}

Wang, Hui-Ping ^{[2
]}

Zhao, Wei ^{[1
]}

Qin, Shi-Chun ^{[2
]}

Li, Yong ^{[1
]}

Cai, Hao-Cheng ^{[1
]}

Wang, Wei-Guang ^{[1
,3
]}

Hu, Qiu-Fen ^{[1
,3
]}

Cai, Jie-Yun ^{[1
,2
]}

机构：

[1] China Tobacco Yunnan Ind Co Ltd, Yunnan Key Lab Tobacco Chem, Kunming 650231, Peoples R China

[2] Yunnan Tobacco Qual Supervis & Test Stn, Kunming 650106, Yunnan, Peoples R China

[3] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, Kunming 650031, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2023年 / 59卷 / 06期

关键词：

Nicotiana tabacum; sesquiterpenoids; antibacterial activity; LEAVES;

D O I：

10.1007/s10600-023-04203-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new benzofulvene sesquiterpenoids, tabanoids A and B (1 and 2) as well as five known sesquiterpenoids (3-7) were isolated from the stem of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1 and 2 showed good inhibition with IZD of 15.2 +/- 2.5, and 12.8 +/- 2.2 mm, respectively.

引用

页码：1092 / 1096

页数：5

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