Ferroptosis: An Emerging Target for Bladder Cancer Therapy

被引：7

作者：

Shan, Zhengda ^{[1
]}

Tang, Wenbin ^{[2
]}

Shi, Zhiyuan ^{[2
]}

Shan, Tao ^{[3
]}

机构：

[1] Sun Yat Sen Univ, Sch Med, Shenzhen 518107, Peoples R China

[2] Xiamen Univ, Sch Med, Xiamen 361102, Peoples R China

[3] Qingdao Univ, Sch Basic Med, Qingdao 266071, Peoples R China

来源：

CURRENT ISSUES IN MOLECULAR BIOLOGY | 2023年 / 45卷 / 10期

关键词：

bladder cancer; ferroptosis; mechanism; gene; drug; ERASTIN-INDUCED FERROPTOSIS; CELL-DEATH; IRON; FERROPORTIN; GLUTATHIONE; MECHANISMS; ACTIVATION; PROMOTES; SURVIVAL; IDENTIFICATION;

D O I：

10.3390/cimb45100517

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bladder cancer (BC), as one of the main urological cancers in the world, possesses the abilities of multiple-drug resistance and metastasis. However, there remains a significant gap in the understanding and advancement of prognosis and therapeutic strategies for BC. Ferroptosis, a novel type of iron-dependent regulated cell death, depends on lipid peroxidation, which has been proven to have a strong correlation with the development and treatment of BC. Its mechanism mainly includes three pathways, namely, lipid peroxidation, the antioxidant system, and the iron overload pathway. In this review, we reviewed the mechanism of ferroptosis, along with the related therapeutic targets and drugs for BC, as it might become a new anticancer treatment in the future.

引用

页码：8201 / 8214

页数：14

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