Effect of the Combination of Different Therapies on Oxidative Stress in the Experimental Model of Multiple Sclerosis

被引:4
作者
Escribano, Begona M. [1 ,2 ,8 ,9 ]
Munoz-Jurado, Ana [1 ]
Luque, Evelio [2 ,3 ]
Galvan, Alberto [2 ,4 ]
Latorre, Manuel [2 ]
Caballero-Villarraso, Javier [2 ,4 ,5 ]
Giraldo, Ana I. [2 ,4 ]
Aguera, Eduardo [2 ,6 ]
Tunez, Isaac [2 ,4 ,7 ,8 ,9 ]
机构
[1] Univ Cordoba, Fac Vet Med, Dept Cell Biol Physiol & Immunol, Cordoba, Spain
[2] Maimonides Inst Res Biomed Cordoba IMIBIC, Cordoba, Spain
[3] Univ Cordoba, Fac Med & Nursing, Dept Morphol Sci, Histol Sect, Cordoba, Spain
[4] Univ Cordoba, Fac Med & Nursing, Dept Biochem & Mol Biol, Cordoba, Spain
[5] Reina Sofia Univ Hosp, Anal Serv, Cordoba, Spain
[6] Reina Sofia Univ Hosp, Neurol Serv, Cordoba, Spain
[7] Cooperat Res Themat Excellent Network Brain Stimul, Cordoba, Spain
[8] Dept Biochem & Mol Biol, Fac Med & Nursing, Sect Legal & Forens Med, Ave Menendez Pidal, Cordoba 14004, Spain
[9] Univ Cordoba, Fac Vet Med, Dept Cell Biol Physiol & Immunol, Cordoba 14071, Spain
关键词
oxidative stress; experimental autoimmune encephalomyelitis; S-allylcysteine; extra virgin olive oil; transcranial magnetic stimulation; TRANSCRANIAL MAGNETIC STIMULATION; S-ALLYL CYSTEINE; ANTIOXIDANT; NEURONS; DISEASE; DAMAGE; GLUTATHIONE; NUTRITION; DYSBIOSIS;
D O I
10.1016/j.neuroscience.2023.08.005
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
stress is heavily involved in several pathological features of Multiple Sclerosis (MS), such as myelin destruction, axonal degeneration, and inflammation. Different therapies have been shown to reduce the oxidative stress that occurs in the animal model of MS, experimental autoimmune encephalomyelitis (EAE). Some of these therapies are transcranial magnetic stimulation (TMS), extra virgin olive oil (EVOO) and S-allyl cysteine (SAC). This study aims to test the antioxidant effect of these three therapies, to compare the efficacy of SAC versus TMS and EVOO, and to analyze the effect of combining SAC + TMS and SAC and EVOO. Seventy Dark Agouti rats were used, which were divided into Control group; Vehicle group; Mock group; SAC; EVOO; TMS; SAC + EVOO; SAC + TMS; EAE; EAE + SAC; EAE + EVOO; EAE + TMS; EAE + SAC + EVOO; EAE + SA C + TMS. The TMS consisted of an oscillatory magnetic field in the form of a sine wave with a frequency of 60 Hz and an amplitude of 0.7mT (EL-EMF) applied for two hours in the morning, once a day, five days a week. SAC was administered at a dose of 50 mg/kg body weight, orally daily, five days a week. EVOO represented 10% of their calorie intake in the total standard daily diet of rats AIN-93G. All treatments were maintained for 51 days. TMS, EVOO and SAC, alone or in combination, reduce oxidative stress, increasing antioxidant defenses and also lowering the clinical score. Combination therapies do not appear to be more potent than individual therapies against the oxidative stress of EAE or its clinical symptoms.(c) 2023 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:116 / 128
页数:13
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