Hyperpolarized [2-13C]pyruvate MR molecular imaging with whole brain coverage

被引：6

作者：

Chung, Brian T. ^{[1
,2
]}

Kim, Yaewon ^{[1
]}

Gordon, Jeremy W. ^{[1
]}

Chen, Hsin-Yu ^{[1
]}

Autry, Adam W. ^{[1
]}

Lee, Philip M. ^{[1
,2
]}

Hu, Jasmine Y. ^{[1
,2
]}

Tan, Chou T. ^{[3
]}

Suszczynski, Chris ^{[3
]}

Chang, Susan M. ^{[4
]}

Villanueva-Meyer, Javier E. ^{[1
]}

Bok, Robert A. ^{[1
]}

Larson, Peder E. Z. ^{[1
,2
]}

Xu, Duan ^{[1
,2
]}

Li, Yan ^{[1
]}

Vigneron, Daniel B. ^{[1
,2
,4
]}

机构：

[1] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, 1700 Fourth St,Byers Hall Suite 102, San Francisco, CA 94158 USA

[2] Univ Calif Berkeley, UCSF UC Berkeley Grad Program Bioengn, Berkeley, CA USA

[3] Merck KGaA, ISOTEC Stable Isotope Div, MilliporeSigma, Miamisburg, OH 45342 USA

[4] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94158 USA

来源：

NEUROIMAGE | 2023年 / 280卷

关键词：

Hyperpolarized carbon-13; Molecular imaging; Brain Metabolism; C-13; SPECTROSCOPY; METABOLISM; GLUTAMATE;

D O I：

10.1016/j.neuroimage.2023.120350

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hyperpolarized (HP) 13C Magnetic Resonance Imaging (MRI) was applied for the first time to image and quantify the uptake and metabolism of [2-13C]pyruvate in the human brain to provide new metabolic information on cerebral energy metabolism. HP [2-13C]pyruvate was injected intravenously and imaged in 5 healthy human volunteer exams with whole brain coverage in a 1-minute acquisition using a specialized spectral-spatial multi slice echoplanar imaging (EPI) pulse sequence to acquire 13C-labeled volumetric and dynamic images of [2-13C] pyruvate and downstream metabolites [5-13C]glutamate and [2-13C]lactate. Metabolic ratios and apparent conversion rates of pyruvate-to-lactate (kPL) and pyruvate-to-glutamate (kPG) were quantified to investigate simultaneously glycolytic and oxidative metabolism in a single injection.

引用

页数：8

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