Synthesis, physical properties and cytotoxic assessment of ester-terminated gemini imidazolium surfactants

被引:5
作者
Chauhan, Vinay [1 ]
Kumar, Manish [2 ]
Soni, Isha [1 ]
Shandilya, Pooja [3 ]
Singh, Sukhprit [4 ]
机构
[1] Shoolini Univ, Sch Adv Chem Sci, Solan 173229, India
[2] Cent Univ Himachal Pradesh, Dept Chem & Chem Sci, Kangra 176215, HP, India
[3] Maharishi Markandeshwar Deemed Be Univ, Dept Chem, MMEC, Mullana Ambala 133207, Haryana, India
[4] Guru Nanak Dev Univ, Ctr Adv Studies I, Dept Chem UGC Sponsored, Amritsar 143005, Punjab, India
关键词
Gemini Surfactants; Surface properties; Aggregate size; Stability; Cytotoxicity; IONIC LIQUIDS; AGGREGATION BEHAVIOR; ALKYL CHAIN; ALKYLTRIMETHYLAMMONIUM BROMIDES; ANTIMICROBIAL ACTIVITY; MICELLE FORMATION; SELF-AGGREGATION; AQUEOUS-MEDIUM; MICELLIZATION; SPACER;
D O I
10.1016/j.molliq.2023.122645
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Ester-functionalized gemini imidazolium amphiphiles appended with different spacers have been developed. The desired structures were confirmed using mass spectroscopy and NMR techniques. With the help of tensiometry, conductometry, and spectrofluorometry, the investigated amphiphiles have been characterized for a variety of physical properties including Gibbs free energy of adsorption (& UDelta;G0ads), C20 (surfactant concentration required to reduce the surface tension of the solvent by 20 mN & BULL;m  1), maximum surface excess (Ʈmax), critical micelle concentration (cmc), Gibbs free energy of the micellization (& UDelta;G0mic) and Amin (minimum surface area/molecule). Dynamic light scattering (DLS) measurements were taken to examine aggregate size distribution and zeta potential. Thermal decomposition temperature of investigated amphiphiles was determined from thermogravimetric analysis (TGA) analysis. By using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the toxicity of examined amphiphiles towards the C6 glioma cell line was assessed. The physicochemical study of these surfactants revealed that varying spacer length considerably affects the properties.
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页数:8
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