Vitamin E (α-Tocopherol) Does Not Ameliorate the Toxic Effect of Bisphenol S on the Metabolic Analytes and Pancreas Histoarchitecture of Diabetic Rats

被引:1
作者
Pena-Corona, Sheila I. I. [1 ]
Vargas-Estrada, Dinorah [2 ]
Chavez-Corona, Juan I. I. [2 ]
Adriana Mendoza-Rodriguez, C. [3 ]
Caballero-Chacon, Sara [2 ]
Pedraza-Chaverri, Jose [3 ]
Isabel Gracia-Mora, Maria [4 ]
Patricia Galvan-Vela, Diana [5 ]
Garcia-Rodriguez, Helena [5 ]
Sanchez-Bartez, Francisco [4 ]
Vergara-Onofre, Marcela [6 ]
Leyva-Gomez, Gerardo [1 ]
机构
[1] Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Ciudad De Mexico 04510, Mexico
[2] Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Dept Fisiol & Farmacol, Ciudad De Mexico 04510, Mexico
[3] Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Ciudad De Mexico 04510, Mexico
[4] Univ Nacl Autonoma Mexico, Fac Quim, Dept Quim Inorgan & Nucl, Ciudad De Mexico 04510, Mexico
[5] Univ Nacl Autonoma Mexico, Fac Quim, Unidad Invest Preclin UNIPREC, Ciudad De Mexico 04510, Mexico
[6] Univ Autonoma Metropolitana, Unidad Xochimilco, Dept Prod Agr & Anim, Ciudad De Mexico 04960, Mexico
关键词
bisphenol S; endocrine-disrupting compounds; diabetic rats; vitamin E; biochemistry; INDUCED REPRODUCTIVE TOXICITY; OXIDATIVE STRESS; STREPTOZOTOCIN; ANTIOXIDANT; ANALOGS; SUPPLEMENTATION; ABSORPTION; EXPOSURE; TISSUE; ABNORMALITIES;
D O I
10.3390/toxics11070626
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
This study investigated whether the coadministration of vitamin E (VitE) diminishes the harmful effects provoked by plasticizer bisphenol S (BPS) in the serum metabolites related to hepatic and renal metabolism, as well as the endocrine pancreatic function in diabetic male Wistar rats. Rats were divided into five groups (n = 5-6); the first group was healthy rats (Ctrl group). The other four groups were diabetic rats induced with 45 mg/kg bw of streptozotocin: Ctrl-D (diabetic control); VitE-D (100 mg/kg bw/d of VitE); BPS-D (100 mg/kg bw/d of BPS); The animals from the VitE + BPS-D group were administered 100 mg/kg bw/d of VitE + 100 mg/kg bw/d of BPS. All compounds were administered orally for 30 days. Body weight, biochemical assays, urinalysis, glucose tolerance test, pancreas histopathology, proximate chemical analysis in feces, and the activity of antioxidants in rat serum were assessed. The coadministration of VitE + BPS produced weight losses, increases in 14 serum analytes, and degeneration in the pancreas. Therefore, the VitE + BPS coadministration did not have a protective effect versus the harmful impact of BPS or the diabetic metabolic state; on the contrary, it partially aggravated the damage produced by the BPS. VitE is likely to have an additive effect on the toxicity of BPS.
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页数:24
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