Enantioselective 1,3-Dipolar Cycloaddition of Aryldiazoalkanes Catalyzed by Chiral Oxazaborolidinium Ions

被引：2
|
作者：
Seo, Terim [1 ]
Park, Kyung Yee [1 ]
Kim, Jae Yeon [1 ]
Ryu, Do Hyun [1 ]
机构：
[1] Sungkyunkwan Univ, Dept Chem, 300 Cheoncheon Dong, Suwon 16419, South Korea
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 12卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
diazo compounds; 1,3-dipolar cycloaddition; enantioselectivity; pyrazolines; alpha; beta-unsaturated esters; C-H BOND; DIAZO-COMPOUNDS; CARBON INSERTION; ALPHA-TERTIARY; ACCESS; CYCLOPROPANATION; CYCLOALKANONES; DIAZOACETATES; EFFICIENT; HOMOLOGATION;
D O I：
10.1002/ajoc.202300288
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Non-stabilized aryldiazoalkanes were utilized for highly enantioselective catalytic 1,3-dipolar cycloaddition reaction in the presence of chiral oxazaborolidinium ion (COBI) as a Lewis acid catalyst. Enantioenriched 2-pyrazolines were obtained in excellent yields (up to > 99%) with excellent enantioselectivities (up to > 99%).
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页数：4
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