SOHO State of the Art Updates and Next Questions | Optimal Timing of Blinatumomab for the Treatment of B-Acute Lymphoblastic Leukemia

被引：2

作者：

Pinchinat, Ashley ^{[1
]}

Gupta, Sumit ^{[2
,3
]}

Cooper, Stacy L. ^{[4
]}

Rau, Rachel E. ^{[5
,6
]}

机构：

[1] Hassenfeld Childrens Hosp NYU Langone Hlth, NYU Grossman Sch Med, Dept Pediat, Div Pediat Hematol Oncol, New York, NY USA

[2] Hosp Sick Children, Div Haematol Oncol, Toronto, ON, Canada

[3] Univ Toronto, Fac Med, Toronto, ON, Canada

[4] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD USA

[5] Baylor Coll Med, Texas Childrens Hosp, Dept Pediat, Houston, TX USA

[6] 1102 Bates Ave,Ste 1025-20, Houston, TX 77030 USA

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2023年 / 23卷 / 03期

关键词：

B; -ALL; Immunotherapy; Minimal residual disease; MINIMAL RESIDUAL DISEASE; ADULT PATIENTS; SINGLE-ARM; PHASE-II; INOTUZUMAB OZOGAMICIN; MOLECULAR RESPONSE; FREE SURVIVAL; YOUNG-ADULTS; T-CELLS; CHEMOTHERAPY;

D O I：

10.1016/j.clml.2022.12.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Blinatumomab is a CD19 targeting bi-specific T-cell engager antibody construct developed for the treatment of CD19 expressing B-cell malignancies. Numerous adult and pediatric B-ALL clinical trials have demonstrated blinatumomab's efficacy in the relapse setting as well as in patients with residual disease after upfront chemotherapy. The safety profile of blinatumomab is also favorable, making it a feasible option for most patients. Several key questions remain, including the role of blinatumomab as a replacement for toxic elements of standard chemotherapy regimens in the upfront setting, its role as a bridge to hematopoietic stem cell transplantation, or whether previous blinatumomab impacts the efficacy of subsequent CAR-T cell therapy.

引用

页码：159 / 167

页数：9

共 63 条

[1] SWOG 1318: A Phase II Trial of Blinatumomab Followed by POMP Maintenance in Older Patients With Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia [J].

Advani, Anjali S. ;

Moseley, Anna ;

O'Dwyer, Kristen M. ;

Wood, Brent L. ;

Fang, Min ;

Wieduwilt, Matthew J. ;

Aldoss, Ibrahim ;

Park, Jae H. ;

Klisovic, Rebecca B. ;

Baer, Maria R. ;

Stock, Wendy ;

Bhave, Rupali R. ;

Othus, Megan ;

Harvey, Richard C. ;

Willman, Cheryl L. ;

Litzow, Mark R. ;

Stone, Richard M. ;

Sharon, Elad ;

Erba, Harry P. .

JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (14) :1574-+

[2] Tumor regression in cancer patients by very low doses of a T cell-engaging antibody [J].

Bargou, Ralf ;

Leo, Eugen ;

Zugmaier, Gerhard ;

Klinger, Matthias ;

Goebeler, Mariele ;

Knop, Stefan ;

Noppeney, Richard ;

Viardot, Andreas ;

Hess, Georg ;

Schuler, Martin ;

Einsele, Hermann ;

Brandl, Christian ;

Wolf, Andreas ;

Kirchinger, Petra ;

Klappers, Petra ;

Schmidt, Margit ;

Riethmueller, Gert ;

Reinhardt, Carsten ;

Baeuerle, Patrick A. ;

Kufer, Peter .

SCIENCE, 2008, 321 (5891) :974-977

[3]

Brown PA, 2021, BLOOD, V138

[4] Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia A Randomized Clinical Trial [J].

Brown, Patrick A. ;

Ji, Lingyun ;

Xu, Xinxin ;

Devidas, Meenakshi ;

Hogan, Laura E. ;

Borowitz, Michael J. ;

Raetz, Elizabeth A. ;

Zugmaier, Gerhard ;

Sharon, Elad ;

Bernhardt, Melanie B. ;

Terezakis, Stephanie A. ;

Gore, Lia ;

Whitlock, James A. ;

Pulsipher, Michael A. ;

Hunger, Stephen P. ;

Loh, Mignon L. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (09) :833-842

[5] A Randomized Phase 3 Trial of Blinatumomab Vs. Chemotherapy As Post-Reinduction Therapy in High and Intermediate Risk (HR/IR) First Relapse of B-Acute Lymphoblastic Leukemia (B-ALL) in Children and Adolescents/Young Adults (AYAs) Demonstrates Superior Efficacy and Tolerability of Blinatumomab: A Report from Children's Oncology Group Study AALL1331 [J].

Brown, Patrick A. ;

Ji, Lingyun ;

Xu, Xinxin ;

Devidas, Meenakshi ;

Hogan, Laura ;

Borowitz, Michael J. ;

Raetz, Elizabeth A. ;

Zugmaier, Gerhard ;

Sharon, Elad ;

Gore, Lia ;

Whitlock, James A. ;

Pulsipher, Michael A. ;

Hunger, Stephen P. ;

Loh, Mignon L. .

BLOOD, 2019, 134

[6] High tumor burden before blinatumomab has a negative impact on the outcome of adult patients with B-cell precursor acute lymphoblastic leukemia. A real-world study by the GRAALL [J].

Cabannes-Hamy, Aurelie ;

Brissot, Eolia ;

Leguay, Thibaut ;

Huguet, Francoise ;

Chevallier, Patrice ;

Hunault, Mathilde ;

Escoffre-Barbe, Martine ;

Cluzeau, Thomas ;

Balsat, Marie ;

Nguyen, Stephanie ;

Pasquier, Florence ;

Alexis, Magda ;

Lheritier, Veronique ;

Pastoret, Cedric ;

Delabesse, Eric ;

Clappier, Emmanuelle ;

Dombret, Herve ;

Boissel, Nicolas .

HAEMATOLOGICA, 2022, 107 (09) :2072-2080

[7]

Chiaretti S, 2022, P353 40 MONTHS UPDAT, V6, P253

[8] Blinatumomab for infant acute lymphoblastic leukemia [J].

Clesham, Katherine ;

Rao, Vasudha ;

Bartram, Jack ;

Ancliff, Philip ;

Ghorashian, Sara ;

O'Connor, David ;

Pavasovic, Vesna ;

Rao, Anupama ;

Samarasinghe, Sujith ;

Cummins, Michelle ;

Malone, Andrea ;

Patrick, Katharine ;

Bonney, Denise ;

James, Beki ;

Gibson, Brenda ;

Vora, Ajay .

BLOOD, 2020, 135 (17) :1501-1504

[9] Blinatumomab versus chemotherapy in first salvage or in later salvage for B-cell precursor acute lymphoblastic leukemia [J].

Dombret, Herve ;

Topp, Max S. ;

Schuh, Andre C. ;

Wei, Andrew H. ;

Durrant, Simon ;

Bacon, Christopher Larry ;

Qui Tran ;

Zimmerman, Zachary ;

Kantarjian, Hagop .

LEUKEMIA & LYMPHOMA, 2019, 60 (09) :2214-2222

[10] Determinants of CD19-positive vs CD19-negative relapse after tisagenlecleucel for B-cell acute lymphoblastic leukemia [J].

Dourthe, Marie-Emilie ;

Rabian, Florence ;

Yakouben, Karima ;

Chevillon, Florian ;

Cabannes-Hamy, Aurelie ;

Mechinaud, Francoise ;

Grain, Audrey ;

Chaillou, Delphine ;

Rahal, Ilhem ;

Caillat-Zucman, Sophie ;

Lesprit, Emmanuelle ;

Naudin, Jerome ;

Roupret-Serzec, Julie ;

Parquet, Nathalie ;

Brignier, Anne ;

Guerin-El Khourouj, Valerie ;

Lainey, Elodie ;

Caye-Eude, Aurelie ;

Cave, Helene ;

Clappier, Emmanuelle ;

Mathis, Stephanie ;

Azoulay, Elie ;

Dallel, Jean Hugues ;

Dhedin, Nathalie ;

Madelaine, Isabelle ;

Larghero, Jerome ;

Boissel, Nicolas ;

Baruchel, Andre .

LEUKEMIA, 2021, 35 (12) :3383-3393

← 1 2 3 4 5 6 7 →