Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy

被引:27
作者
Qi, Qingwen [1 ]
Wang, Qian [1 ]
Li, Yuhao [1 ,2 ]
Silva, Dionisio Zaldivar [2 ,3 ]
Ruiz, Maria Eliana Lanio [2 ,3 ]
Ouyang, Ruizhuo [1 ,2 ]
Liu, Baolin [2 ,4 ]
Miao, Yuqing [1 ,2 ]
机构
[1] Univ Shanghai Sci & Technol, Inst Bismuth & Rhenium, Sch Mat & Chem, Shanghai 200093, Peoples R China
[2] Univ Shanghai Sci & Technol, USST UH Int Joint Lab Tumor Diag & Energy Treatmen, Shanghai 200093, Peoples R China
[3] Univ Havana, Fac Biol, Havana 10400, Cuba
[4] Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, Shanghai 200093, Peoples R China
基金
上海市自然科学基金;
关键词
rhenium; complexes; nanomaterials; cancer therapy; imaging; CANCER-CELL METABOLISM; IN-VIVO; DNA-BINDING; PHOTODYNAMIC THERAPY; ANTICANCER ACTIVITY; TRICARBONYL COMPLEXES; CONTRAST AGENT; RE-188; NANOPARTICLES; CYTOTOXICITY;
D O I
10.3390/molecules28062733
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rhenium (Re) is widely used in the diagnosis and treatment of cancer due to its unique physical and chemical properties. Re has more valence electrons in its outer shell, allowing it to exist in a variety of oxidation states and to form different geometric configurations with many different ligands. The luminescence properties, lipophilicity, and cytotoxicity of complexes can be adjusted by changing the ligand of Re. This article mainly reviews the development of radionuclide Re-188 in radiotherapy and some innovative applications of Re as well as the different therapeutic approaches and imaging techniques used in cancer therapy. In addition, the current application and future challenges and opportunities of Re are also discussed.
引用
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页数:23
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