CD8+ T cell metabolic changes in breast cancer

被引：4

作者：

Castoldi, Angela ^{[1
,2
,3
]}

Lee, Jennifer ^{[4
,5
,6
]}

Carvalho, Daniel de Siqueira ^{[3
]}

Souto, Fabricio Oliveira ^{[1
,2
,3
]}

机构：

[1] Univ Fed Pernambuco, Inst Keizo Asami, Recife, PE, Brazil

[2] Univ Fed Pernambuco, Ctr Acad Agreste, Nucleo Ciencias Vida, Caruaru, Brazil

[3] Univ Fed Pernambuco, Programa Posgrad Biol Aplicada Saude, Recife, PE, Brazil

[4] Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, 330 Brookline Ave, Boston, MA 02215 USA

[5] Harvard Med Sch, 330 Brookline Ave, Boston, MA 02215 USA

[6] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Sch Med, 711 Washington St, Boston, MA 02111 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2023年 / 1869卷 / 01期

关键词：

Breast cancer; Tumor infiltrating lymphocytes; CD8(+) T cells; Immunometabolism; TUMOR-INFILTRATING LYMPHOCYTES; PROGNOSTIC VALUE; GLUTAMINE UPTAKE; PD-1; EXPRESSION; AUTOPHAGY; MITOCHONDRIAL; MEMORY; ACID; SURVIVAL; MICROENVIRONMENT;

D O I：

10.1016/j.bbadis.2022.166565

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immunometabolism has advanced our understanding of how the cellular environment and nutrient availability regulates immune cell fate. Not only are metabolic pathways closely tied to cell signaling and differentiation, but can induce different subsets of immune cells to adopt unique metabolic programs, influencing disease progression. Dysregulation of immune cell metabolism plays an essential role in the progression of several diseases including breast cancer (BC). Metabolic reprogramming plays a critical role in regulating T cell functions. CD8(+) T cells are an essential cell type within the tumor microenvironment (TME). To induce antitumor responses, CD8(+) T cells need to adapt their metabolism to fulfill their energy requirement for effective function. However, different markers and immunologic techniques have made identifying specific CD8(+) T cells subtypes in BC a challenge to the field. This review discusses the immunometabolic processes of CD8(+) T cell in the TME in the context of BC and highlights the role of CD8+ T cell metabolic changes in tumor progression.

引用

页数：11

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