Prognostic and predictive biomarkers for immunotherapy in advanced renal cell carcinoma

被引：155

作者：

Rosellini, Matteo ^{[1
]}

Marchetti, Andrea ^{[1
]}

Mollica, Veronica ^{[1
]}

Rizzo, Alessandro ^{[2
]}

Santoni, Matteo ^{[3
]}

Massari, Francesco ^{[1
,4
]}

机构：

[1] Univ Bologna, Med Oncol, IRCCS Azienda Osped, Bologna, Italy

[2] IRCCS, Dipartimentale Oncol Med Presa Car Globale Pazien, Struttura Semplice, Ist Tumori Giovanni Paolo II, Bari, Italy

[3] Macerata Hosp, Oncol Unit, Macerata, Italy

[4] Univ Bologna, Dept Expt Diagnost & Specialty Med, Bologna, Italy

来源：

NATURE REVIEWS UROLOGY | 2023年 / 20卷 / 03期

关键词：

TYROSINE KINASE INHIBITORS; TUMOR MUTATIONAL BURDEN; CHECKPOINT INHIBITORS; CANCER-IMMUNOTHERAPY; ANTI-PD-1; THERAPY; PROMOTES INVASION; TARGETED THERAPY; PARP INHIBITORS; PATIENTS PTS; LUNG-CANCER;

D O I：

10.1038/s41585-022-00676-0

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The therapeutic algorithm of renal cell carcinoma has been revolutionized by the approval of immunotherapy agents by regulatory agencies. However, objective and durable responses are still not observed in a large number of patients, and prognostic and predictive biomarkers for immunotherapy response are urgently needed. Prognostic models used in clinical practice are based on clinical and laboratory factors (such as hypercalcaemia, neutrophil count or Karnofsky Performance Status), but, with progress in molecular biology and genome sequencing techniques, new renal cell carcinoma molecular features that might improve disease course and outcomes prediction have been highlighted. An implementation of current models is needed to improve the accuracy of prognosis in the immuno-oncology era. Moreover, several potential biomarkers are currently under evaluation, but effective markers to select patients who might benefit from immunotherapy and to guide therapeutic strategies are still far from validation. The approval of immunotherapy agents to treat patients with metastatic renal cell carcinoma revolutionized the therapeutic landscape for this disease, but a large number of patients still do not experience objective and durable response, and biomarkers to identify response to immunotherapy are urgently needed. In this Review, the authors describe strength and limitations of currently available prognostic and predictive biomarkers in metastatic renal cell carcinoma and discuss emerging promising biomarkers that deserve further investigation.

引用

页码：133 / 157

页数：25

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