Current molecular biomarkers evaluation in gastric/gastroesophageal junction adenocarcinoma: pathologist does matter

被引：6

作者：

Businello, Gianluca ^{[1
]}

Angerilli, Valentina ^{[1
]}

Lonardi, Sara ^{[2
]}

Bergamo, Francesca ^{[2
]}

Valmasoni, Michele ^{[3
]}

Farinati, Fabio ^{[3
]}

Savarino, Edoardo ^{[3
]}

Spolverato, Gaya ^{[3
]}

Fassan, Matteo ^{[1
,2
]}

机构：

[1] Univ Padua, Dept Med DIMED, Padua, Italy

[2] Ist Ricovero & Cura Carattere Sci IRCCS, Veneto Inst Oncol, Padua, Italy

[3] Univ Padua, Dept Surg Oncol & Gastroenterol DISCOG, Padua, Italy

来源：

UPDATES IN SURGERY | 2023年 / 75卷 / 02期

关键词：

Gastric adenocarcinoma; Gastroesophageal junction adenocarcinoma; Biomarkers; Immunohistochemistry; ADVANCED GASTRIC-CANCER; TYROSINE KINASE INHIBITOR; FGFR2 GENE AMPLIFICATION; DOUBLE-BLIND; OPEN-LABEL; 1ST-LINE THERAPY; HER2; STATUS; PHASE-II; MICROSATELLITE INSTABILITY; GASTROESOPHAGEAL CANCER;

D O I：

10.1007/s13304-022-01330-5

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The comprehensive molecular characterization of gastric and gastroesophageal junction adenocarcinomas has led to the improvement of targeted and more effective treatments. As a result, several biomarkers have been introduced into clinical practice and the implementation of innovative diagnostic tools is under study. Such assessments are mainly based on the evaluation of limited biopsy material in clinical practice. In this setting, the pathologist represents a key player in the selection of patients facilitating precision medicine approaches.

引用

页码：291 / 303

页数：13

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