Investigation of in vitro antimicrobial and cytotoxic effects of gold nanoparticles capped with meropenem and imipenem

被引：3

作者：

Ciftci, Nurullah ^{[1
]}

Sargin, Idris ^{[2
]}

Arslan, Gulsin ^{[2
]}

Karakurt, Serdar ^{[2
]}

Arslan, Ugur ^{[3
]}

机构：

[1] Kafkas Univ, Fac Med, Med Microbiol Dept, TR-36100 Kars, Turkiye

[2] Selcuk Univ, Fac Sci, Biochem Dept, TR-42130 Selcuklu, Turkiye

[3] Selcuk Univ, Fac Med, Med Microbiol Dept, TR-42130 Selcuklu, Turkiye

来源：

NANOMEDICINE | 2023年 / 18卷 / 24期

关键词：

antimicrobial resistance; cell culture; gold nanoparticles; imipenem; meropenem; SILVER NANOPARTICLES; ANTIBACTERIAL ACTIVITY; CARBAPENEMS; NANOMEDICINE; TOXICITY; ANTIBIOTICS; AGENT; SIZE;

D O I：

10.2217/nnm-2023-0223

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: This study aimed to investigate the in vitro antimicrobial effect of gold nanoparticles capped with meropenem and imipenem against various strains and to evaluate the cytotoxic effect of gold nanoparticles on healthy human colon epithelial cells. Materials & methods: Gold nanoparticles were synthesized via the Turkevich method and tested for antimicrobial effects using broth microdilution. Cell culture studies were performed using a cytotoxicity assay with alamarBlue (TM). Results & conclusion: Nanoparticles (10-20 nm) with antibiotic coating were more effective against Escherichia coli, Proteus spp. and Serratia marcescens than pure antibiotics. They had a cytotoxic effect on cells at high concentrations but were safe at low concentrations.

引用

页码：1719 / 1731

页数：13

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