Molecular Profiling and Targeted Therapies in Gliomas

被引：3
作者：
Felistia, Yuli [1 ]
Wen, Patrick Y. [2 ,3 ]
机构：
[1] Natl Brain Ctr Hosp, Neurooncol Div, Jakarta, Indonesia
[2] Brigham & Womens Hosp, Dana Farber Canc Inst, Ctr Neurooncol,Div Neurooncol, Dept Neurol, 450 Brookline Ave, Boston, MA 02215 USA
[3] Harvard Med Sch, 450 Brookline Ave, Boston, MA 02215 USA
来源：
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2023年 / 23卷 / 10期
关键词：
Molecular profiling; Targeted therapy; Glioma; Glioblastoma; CENTRAL-NERVOUS-SYSTEM; DABRAFENIB PLUS TRAMETINIB; METASTATIC BREAST-CANCER; GRADE GLIOMA; PHASE-II; INHIBITOR; RECURRENT; TUMORS; CLASSIFICATION; CRIZOTINIB;
D O I：
10.1007/s11910-023-01299-7
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Purpose of ReviewMolecular profiling enables the evaluation of genetic alterations for the diagnosis and classification of gliomas and the selection of appropriate therapies. This review summarizes the current role of molecular profiling and targeted therapies for gliomas.Recent FindingsMolecular profiling is an integral part of the 2021 WHO classification of gliomas. Progress in the development of targeted therapies remains limited due to many factors including the presence of the blood-brain barrier and issues of tumor heterogeneity. Nonetheless, advances have been made with the IDH1/2 inhibitor vorasidenib for IDH-mutant grade 2 gliomas, the combination of dabrafenib and trametinib for BRAFV600E mutated gliomas, and the therapies for subsets of patients with fusions and H3K27M-altered diffuse midline gliomas.SummaryWhile there has been progress in the use of molecular profiling for the classification and treatment of gliomas, much work remains for targeted therapies to realize their potential.
引用
收藏
页码：627 / 636
页数：10
相关论文
共 92 条
  • [1] Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer
    Andre, T.
    Shiu, K-K
    Kim, T. W.
    Jensen, B., V
    Jensen, L. H.
    Punt, C.
    Smith, D.
    Garcia-Carbonero, R.
    Benavides, M.
    Gibbs, P.
    de la Fouchardiere, C.
    Rivera, F.
    Elez, E.
    Bendell, J.
    Le, D. T.
    Yoshino, T.
    Van Cutsem, E.
    Yang, P.
    Farooqui, M. Z. H.
    Marinello, P.
    Diaz, L. A., Jr.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (23) : 2207 - 2218
  • [2] Crizotinib versus Chemotherapy in Advanced ALK-Positive Lung Cancer (vol 368, pg 2385, 2013)
    不详
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (16) : 1582 - 1582
  • [3] Advanced molecular diagnostic tools: A step closer to precision medicine in neuro-oncology
    Aquilanti, Elisa
    Wen, Patrick Y.
    [J]. NEURO-ONCOLOGY, 2023, 25 (10) : 1750 - 1751
  • [4] ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma
    Arrieta, Victor A.
    Chen, Andrew X.
    Kane, J. Robert
    Kang, Seong Jae
    Kassab, Cynthia
    Dmello, Crismita
    Zhao, Junfei
    Burdett, Kirsten B.
    Upadhyayula, Pavan S.
    Lee-Chang, Catalina
    Shilati, Joseph
    Jaishankar, Dinesh
    Chen, Li
    Gould, Andrew
    Zhang, Daniel
    Yuan, Jinzhou
    Zhao, Wenting
    Ling, Xiaoyang
    Burks, Jared K.
    Laffleur, Brice
    Amidei, Christina
    Bruce, Jeffrey N.
    Lukas, Rimas, V
    Yamaguchi, Jonathan T.
    Cieremans, David
    Rothschild, Gerson
    Basu, Uttiya
    McCord, Matthew
    Brat, Daniel J.
    Zhang, Hui
    Cooper, Lee A. D.
    Zhang, Bin
    Sims, Peter
    Cloughesy, Tim F.
    Prins, Robert
    Canoll, Peter
    Stupp, Roger
    Heimberger, Amy B.
    Horbinski, Craig
    Iwamoto, Fabio M.
    Rabadan, Raul
    Sonabend, Adam M.
    [J]. NATURE CANCER, 2021, 2 (12) : 1372 - +
  • [5] Biological activity of weekly ONC201 in adult recurrent glioblastoma patients
    Arrillaga-Romany, Isabel
    Odia, Yazmin
    Prabhu, Varun V.
    Tarapore, Rohinton S.
    Merdinger, Krystal
    Stogniew, Martin
    Oster, Wolfgang
    Allen, Joshua E.
    Mehta, Minesh
    Batchelor, Tracy T.
    Wen, Patrick Y.
    [J]. NEURO-ONCOLOGY, 2020, 22 (01) : 94 - 102
  • [6] Lorlatinib in a Child with ALK-Fusion-Positive High- Grade Glioma
    Bagchi, Aditi
    Orr, Brent A.
    Campagne, Olivia
    Dhanda, Sandeep
    Nair, Sreenath
    Tran, Quynh
    Christensen, Anthony M.
    Gajjar, Amar
    Furtado, Larissa V.
    Vasilyeva, Aksana
    Boop, Frederick
    Stewart, Clinton
    Robinson, Giles W.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (08) : 761 - 763
  • [7] Longitudinal molecular trajectories of diffuse glioma in adults
    Barthel, Floris P.
    Johnson, Kevin C.
    Varn, Frederick S.
    Moskalik, Anzhela D.
    Tanner, Georgette
    Kocakavuk, Emre
    Anderson, Kevin J.
    Abiola, Olajide
    Aldape, Kenneth
    Alfaro, Kristin D.
    Alpar, Donat
    Amin, Samirkumar B.
    Ashley, David M.
    Bandopadhayay, Pratiti
    Barnholtz-Sloan, Jill S.
    Beroukhim, Rameen
    Bock, Christoph
    Brastianos, Priscilla K.
    Brat, Daniel J.
    Brodbelt, Andrew R.
    Bruns, Alexander F.
    Bulsara, Ketan R.
    Chakrabarty, Aruna
    Chakravarti, Arnab
    Chuang, Jeffrey H.
    Claus, Elizabeth B.
    Cochran, Elizabeth J.
    Connelly, Jennifer
    Costello, Joseph F.
    Finocchiaro, Gaetano
    Fletcher, Michael N.
    French, Pim J.
    Gan, Hui K.
    Gilbert, Mark R.
    Gould, Peter V.
    Grimmer, Matthew R.
    Iavarone, Antonio
    Ismail, Azzam
    Jenkinson, Michael D.
    Khasraw, Mustafa
    Kim, Hoon
    Kouwenhoven, Mathilde C. M.
    LaViolette, Peter S.
    Li, Meihong
    Lichter, Peter
    Ligon, Keith L.
    Lowman, Allison K.
    Malta, Tathiane M.
    Mazor, Tali
    McDonald, Kerrie L.
    [J]. NATURE, 2019, 576 (7785) : 112 - +
  • [8] Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial
    Bartsch, Rupert
    Berghoff, Anna Sophie
    Furtner, Julia
    Marhold, Maximilian
    Bergen, Elisabeth Sophie
    Roider-Schur, Sophie
    Starzer, Angelika Martina
    Forstner, Heidrun
    Rottenmanner, Beate
    Dieckmann, Karin
    Bago-Horvath, Zsuzsanna
    Haslacher, Helmuth
    Widhalm, Georg
    Ilhan-Mutlu, Aysegul
    Minichsdorfer, Christoph
    Fuereder, Thorsten
    Szekeres, Thomas
    Oehler, Leopold
    Gruenberger, Birgit
    Singer, Christian F.
    Weltermann, Ansgar
    Puhr, Rainer
    Preusser, Matthias
    [J]. NATURE MEDICINE, 2022, 28 (09) : 1840 - +
  • [9] World Health Organization 2021 Classification of Central Nervous System Tumors and Implications for Therapy for Adult-Type Gliomas A Review
    Berger, Tamar R.
    Wen, Patrick Y.
    Lang-Orsini, Melanie
    Chukwueke, Ugonma N.
    [J]. JAMA ONCOLOGY, 2022, 8 (10) : 1493 - 1501
  • [10] Dabrafenib plus Trametinib in Pediatric Glioma with BRAF V600 Mutations
    Bouffet, Eric
    Hansford, Jordan R.
    Garre, Maria Luisa
    Hara, Junichi
    Plant-Fox, Ashley
    Aerts, Isabelle
    Locatelli, Franco
    van der Lugt, Jasper
    Papusha, Ludmila
    Sahm, Felix
    Tabori, Uri
    Cohen, Kenneth J.
    Packer, Roger J.
    Witt, Olaf
    Sandalic, Larissa
    Bento Pereira da Silva, Ana
    Russo, Mark
    Hargrave, Darren R.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2023, 389 (12) : 1108 - 1120
12345678910