Meta-analysis of Shugan Jieyu Capsule for depression in patients with coronary heart disease

Introduction: Shugan Jieyu Capsule (SGJYC) has been prescribed to treat primary and secondary depression; however, whether it can benefit depression of patients with coronary heart disease (CHD) remains controversial. This meta-analysis aimed to evaluate the efficacy and safety of SGJYC in treating depression in patients with CHD. Patient concerns: A total of 644 CHD patients with depression were selected from China National Knowledge Infrastructure, Wanfang, China Biomedical Database, MEDLINE, the Cochrane library from their inceptions until June, 2021. Diagnosis: All patients with CHD or coronary artery disease were confirmed to suffer from depression based on recognized criteria. Intervention: Patients were assigned randomly to receive SGJYC-based regimens or conventional antidepressants alone. Outcomes: Meta-analysis of 6 studies showed that antidepressants (MD, 2.12; 95% confidence interval [CI], 0.73 similar to 3.50) or sertraline (MD, 2.15; 95%CI, 0.61 similar to 3.68) significantly alleviated depression level compared to SGJYC; however, SGJYC plus antihypertensive drugs (AHD) (MD, -8.33; 95%CI, -13.90 similar to -2.75) significantly improved depression symptoms compared to AHD. A significant difference in risk of adverse cardiac events (risk ratios [RR], 2.72; 95%CI, 1.07 similar to 6.94) between SGJYC and sertraline was detected in patients with simple CHD. Conclusions: SGJYC has a poor effect on depressive symptoms, and the effect of combination with AHD is better than AHD but its efficacy and cardiac safety are inferior to antidepressants.